... nucleotides 480 (A to G) [94], 481 (A to G) [129], and 472 (C to U) [194], respectively, each denoted by a star, confer attenuation in the CNS and deficient replication in neuroblastoma cells [106, ... sero-types 1, 2, and 3, respectively) localize to the IRES(domain V) (Fig. 2) and their presence has been linked to deficiencies in viral replication in the CNS and in neurob-lastoma cells [106,107] ... transformingvaccines and immunization against PV into a top priorityof governments, vaccine producers, and public healthexperts, de Quadros was able to institute teams to furtherhis cause...