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Báo cáo hóa học: " Designed hybrid TPR peptide targeting Hsp90 as a novel anticancer agent" docx

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Báo cáo hóa học: " Designed hybrid TPR peptide targeting Hsp90 as a novel anticancer agent" docx

... 9:8http://www.translational-medicine.com/content/9/1/8Page 7 of 12RESEARCH Open Access Designed hybrid TPR peptide targeting Hsp90 as a novel anticancer agentTomohisa Horibe, Masayuki Kohno, Mari Haramoto, ... carboxytetramethyl rhodamine(TAMRA)-labeled Antp -TPR (Antp -TPR- TAMRA) or TPR (TPR- TAMRA) as indicated. Cells were then analyzed by phase-contrast (DIC), fluorescence(TAMRA-red) or merge image ... article as: Horibe et al.: Designed hybrid TPR peptide targeting Hsp90 as a novel anticancer agent. Journal of Translational Medicine 20119:8.Submit your next manuscript to BioMed Centraland...
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báo cáo hóa học: " Methyl salicylate 2-O-b-D-lactoside, a novel salicylic acid analogue, acts as an antiinflammatory agent on microglia and astrocytes" docx

... C, Mollica A, Iannitelli DAE,Cataldi A, Zara S, Nasuti C, Di Stefano A: Ibuprofen and GlutathioneConjugate as a Potential Therapeutic Agent for Treating Alzheimer’sDisease. Arch Pharm (Weinheim) ... expression.Neuroinflammation, represented by activated microgliaand astrocytes, is a prominent pathological feature thatcontributestoneurodegenerationinAD.InADbrain,activated microglia release a variety ... COX-1 activity alone.At least thr ee independent experiments were used fordata analysis. All data are presented as mean ± S.E.M.Values were compared using a t-test (two groups) orone-way ANOVA...
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báo cáo hóa học: " Patterns of pulmonary dysfunction in asbestos workers: a cross-sectional study" docx

... washout vol-ume was 1 L and for those with FVC of less than 2 L, thewashout volume was 0.5 L. A pulmonary gas analyzer(GC-1, Shanghai, China) was used for gas analysis. DLCOwas calculated using ... not have radiographic asbes-tosis or emphysema (Table 5). As expected, pack-years ofsmoking was significantly associated with FEV1 andFEV1/FVC ratio. Similarly, the pack-years variable wassignificantly ... used as surrogate measure of total asbestos exposure.Clinical EvaluationUsing a Chinese standardized respiratory questionnaire,which was based on Medical Research Council Question-naire [37],...
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Báo cáo hóa học: " Discovery of frameshifting in Alphavirus 6K resolves a 20-year enigma" docx

... overscores.CGGGCGCACGCAGCUAGUGUGGCAGAGACU A UGGCCUACUUGUGGGACCAAAACCAAGCGUUGUUCUGGUUGGAGUUUGCGGCCCCUGUUGCCUGCAUCCUCAUCAUCACGU A UUGCCUCAGAAACGUGCUGUGUUGCUGUAAGAGCCUUUCUUUUUUAGUGCUACUGAGCCUCGGGGCAACCGCCAGAGCUUACGAACAUUCGACAGUAAUGCCGAACGUGGUGGGGUUCCCGU A UAAGRAHAASVAETMAYLWDQNQALFWLEFAAPVACI ... 41TF(GCCTTTCTTTTTTAGTGCTACTTAGCCTCGGGGC) and41TR (GCCCCGAGGCTAAGTAGCACTAAAAAAGAAAGGC). PCR product was then transformed into DH5αT1cells (InVitrogen) and plated on Ampicillin-LB plates.Propagated plasmids ... efficiency (dual luciferase assays with inserts comprising the U UUU UUA motif and 3'-adjacent sequence; B Chung et al, in preparation). Base variations that maintain base-pairings are marked in...
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báo cáo hóa học:" Comparisons of three polyethyleneimine-derived nanoparticles as a gene therapy delivery system for renal cell carcinoma" pot

... was decreased [18], which was also su pported bythe FA-PEAs:pVHL polyplexes.Similarly, the transfection efficiency of FA-PEAs andHPEI was increased and the cytotoxicity w as decreasedcompared ... PEI:pVHLcomplexes was larger than the FA-PEAs:pVHL com-plexes obviously at same ratio. Generally, the particlesize of FA-PEAs:pVHL complexes was decreased alongwith the increase of the weight ratios between ... cytotoxicity was acceptable, thecomplexes were kept stable. In addition, the averagezeta potential of FA-PEAs:pVHL complexes at 10:1 ~30:1 mass ratio, was in the range of 7.1 to 31.6 mV,which was a little...
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báo cáo hóa học:" The validity of self-rated health as a measure of health status among young military personnel: evidence from a cross-sectional survey" pot

... Dis-charge was assessed both after BMT and after technicaltraining school, the second level training after BMT, andbefore a participant's permanent duty assignment.Approach to statistical analysesIn ... Thespontaneous assessment perspective posits that ratings ofoverall self rated health are developed based on health sta-tus at any given point in time and fluctuates as health sta-tus changes. Alternatively, ... status were related to higherhealth needs after military deployment. Additional dataare needed so that military leaders can appropriately usedata regarding a military member's assessment...
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Báo cáo hóa học: " Effects of pentacene-doped PEDOT:PSS as a holeconducting layer on the performance characteristics of polymer photovoltaic cells" pot

... donor was pur-chased from Rieke Metal Inc. (Lincoln, NE, USA). PCBM as an electron acceptor was purchased from N ano-C(Westwood, MA, USA). Aluminum as a cathode was pur-chased from CERAC™, Inc. ... devices that the measured hole mobility increases alongwith the increase of the annealing temperature, startingto increas e at a low temperature and saturating at a hightemperature. The pentacene-doped ... was increased, UV-visible transmittance also increased dramatically. By increasing the amountof pentacene in PEDOT:PSS films, dramatic decreases in both the work function and surface resistance...
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báo cáo hóa học: "Fibrillar beta-amyloid peptide Aβ1–40 activates microglial proliferation via stimulating TNF-α release and H2O2 derived from NADPH oxidase: a cell culture study" doc

... when activated by β-amyloid, bacteriaand/or cytokines, the oxidase assembles at the plasmamembrane, and produces superoxide that is releasedextracellularly or into phagosomes at a high rate. ... increase TNF-α levels, to a degreesimilar to that caused by fibrillar A , and this PMA-induced increase was blocked by apocynin and catalase(Fig. 7).The effect of TNF-α neutralisation on A β1–40-induced ... by apocynin and catalase. This suggests thatactivation of NADPH oxidase is sufficient to inducemicroglial proliferation via H2O2 production, and thatactivation of the oxidase by fibrillar...
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báo cáo hóa học:" Lentivirus-mediated RNAi silencing targeting ABCC2 increasing the sensitivity of a human nasopharyngeal carcinoma cell line against cisplatin" docx

... ABCC2-dependingcisplatin resistance in NPC.ABCC2 siRNA increased the intracellular accumulation of cisplatinFigure 2ABCC2 siRNA increased the intracellular accumulation of cisplatin. (A) A typical chromatogram ... 5'-CACCCAGCACAATGAAGAT-3'; ACTBreverse: 5'-CA AATAAAGCCATGCCAAT-3'. Cycling condi-tions were used as described previously [17]: 95°C for 10min to activate DNA polymerase, followed ... genes designed by Primer premier 5.0 software were as follow:ABCC2 forward: 5'-CTC ACTTCAGCGAGACCG-3';ABCC2 reverse: 5'-CCAGCCAGTTCAGGGTTT-3'; ACTBforward: 5'-CACCCAGCACAATGAAGAT-3';...
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báo cáo hóa học:" Optical imaging of the peri-tumoral inflammatory response in breast cancer" docx

... breast can-cer is a well characterized model which recapitulateshuman disease, with progression from hyperplasia toinvasive carcinoma and metastatic disease at ~115 days oflife [3,18]. As ... individuals, such as organ trans-plant recipients, have a lower incidence of breast cancer[1,2]. It has also been noted that as breast cancerprogresses, there is a corresponding increase in thenumber ... and metastasis. Nat Rev Cancer 2004, 4:71-78.19. Jiang H, Iftimia NV, Xu Y, Eggert JA, Fajardo LL, Klove KL: Near-infrared optical imaging of the breast with model-basedreconstruction. Acad...
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