... NODAL, and ACVR2B [32-35].The node containing genes upregulated in EB (node C)included the genes HAND1, HOXA1, HOXB2, MSX1,MSX2, MEIS1, FGF9 and FREM1 which are involved in morphogenesis and ... the expression of 3 genes found by microarray analysis to be upregulated in hES: POU5F1 (OCT4), LEFTY1, and TDGF1, and 2 genes upregulated in EB: HAND1 and GATA5, and 1 gene upregulated in adult ... have beenreported in human [16,17] and mouse embryonic stemcells [18-20]. The unique patterns of miRNA expression in embryonic stem cells suggest they are involved in main-taining "stemness".Identifying...