Báo cáo hóa học: " First-line chemoimmunotherapy in metastatic breast carcinoma: combination of paclitaxel and IMP321 (LAG-3Ig) enhances immune responses and antitumor activity" pptx

... al.: First-line chemoimmunotherapy in metastatic breast carcinoma: combination of paclitaxel and IMP321 (LAG-3Ig) enhances immune responses and antitumor activity. Journal of Translational Medicine ... received IMP321 in three cohorts (doses: 0.25, 1.25 and 6.25 mg). IMP321 induced both a sustained increase in the number and activation of AP...

Ngày tải lên: 18/06/2014, 16:20

... NSC-741909's antitumor cell activity of several LOX inhibitors, including aesculetin (a nonselective LOX inhibitor), MK886 (an inhibitor of the 5-LOX-activating protein), zileuton (a 5-LOX inhibitor), baicalein ... leads to inactivation of MKPs and activation of MAPKs [7-9]. ROS-mediated inhibition of MKPs is critical for TNFα-induced sus- tained activation of JNK and s...

Ngày tải lên: 18/06/2014, 16:20

... then in combination with the nucleoside analogue ribavirin [4]. Current standard of care for chronic HCV infection consists of a regimen of pegylated interferon-α in combi- nation with ribavirin. ... responding to treatment or non-responders, perhaps because of limited power. Gene induction occurred in a cyclic fashion, peaking right after administration of interferon and...

Ngày tải lên: 18/06/2014, 15:20

... purposes) [134]. The immune responses needed to be coordinated both in terms of location (center of the tumor and inva- sive margin (2)) and of orientation with memory and TH1 but not TH2, lack of immune suppression, ... guide- lines of CLIA (Clinical Laboratory Improvements Amend- ments), which include definitions of test accuracy, precision, and reproducibility (...

Ngày tải lên: 18/06/2014, 15:20

... unan- swered issues in this emerging basic and clinical research area in animal models and man toward delineating, e.g., the relative effects of T cells and depletion of Tregs. In the process, the ... inhibiting their effector functions intuitively has the potential of increasing the efficacy of anti-tumour immunity. While increasing pre- clinical data support this hypothe...

Ngày tải lên: 18/06/2014, 15:20

... Falus A: Autocrine and para- crine regulation by cytokines and growth factors in melanoma. Cytokine 2000, 12:547-554. 33. Nicolini A, Carpi A, Rossi G: Cytokines in breast cancer. Cytokine Growth ... Paulomi Aldo and Ms. Irene Visintin for assistance in the experiments involving the xMAP technology, Ms. Jamie Green for editing and proofreading the manuscript, and the UAB Ar...

Ngày tải lên: 18/06/2014, 15:20

... banks, and clinical trial-biobanks. An escalating demand for biospecimens is resulting in the transformation of biobanking from an immature 'cottage industry' con- ducted by individuals, into ... establishment of project teams in 2007 to focus on the three main components of the framework: standardization of biospecimens collec- tion and processing ('Biospecimen...

Ngày tải lên: 18/06/2014, 15:20

... surfaces (e.g., skin, lining of the intestine) against bacteria, and plays a critical role in chronic intestinal inflammation [24,25]. The unchanged IL-17 and IL-23 levels in CFS noted in this study ... evaluation tool in Clinical Med- icine. Clin Chem 1993, 39:561-577. 23. Waldmann TA: The biology of interleukin-2 and interleukin- 15: implications for cancer therapy and v...

Ngày tải lên: 18/06/2014, 15:20

... Tyrrell PJ, Hopkins SJ, Rowland M: Pharmacokinetic modeling of inter- leukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid hemorrhage. Br J Clin Pharmacol ... diseases, including stroke. In the brain, cytokines are expressed not only in the cells of the immune system, but are also produced by resident brain cells, including neurons...

Ngày tải lên: 18/06/2014, 15:20

... group of borderline tumors with no imbalances would, in this line of thinking, have less or no propensity for clonal evolution and development to full-blown carcinomas. Introduction Borderline ... changes giving rise to a more malignant phenotype. The fact that gain of chro- mosomal band 8q23, as well as losses of 19p13 and 19q13, feature p rominently in both overt carcinomas...

Ngày tải lên: 18/06/2014, 16:20