Báo cáo hóa học: " Proton dynamics in cancer" pdf

... started to investigate various aspects of proton dynamics in cancer cells with quite encouraging preliminary results. The intent of unifying investigators involved in this research line led to ... various aspects of proton dynamics in cancer cells, with quite encouraging preliminary results. With the intent of unifying investiga- tors involved in this line of research the Fi...

Ngày tải lên: 18/06/2014, 16:20

... several LOX inhibitors, including aesculetin (a nonselective LOX inhibitor), MK886 (an inhibitor of the 5-LOX-activating protein), zileuton (a 5-LOX inhibitor), baicalein (a 12/15-LOX inhibitor), ... National Cancer Institute. Using a reverse-phase pro- tein microarray assay, we determined molecular changes in 77 protein biomarkers in an oncrasin-sensitive lung cancer cell line after trea...

Ngày tải lên: 18/06/2014, 16:20

... eluted using a salt gradient (0–200 mm NaCl contained in 500 mL buffer A). Following an initial purification using Q-Seph- arose resin a second chromatography step using the same resin was required ... of the flavin does not ‘signal’ a change in the binding geometry. Shifts in substrate position following reduction of a cofactor have been postulated in other enzyme systems, including cy...

Ngày tải lên: 20/02/2014, 02:21

... S-adenosyl methionine domain containing 2 SAMD9 3.8 2.1 3.3 2.6 2.1 2.1 2.0 sterile alpha motif domain containing 9 SERPING1 4.9 1.9 4.1 2.3 1.9 2.0 2.1 serpin peptidase inhibitor, clade G (C1 inhibitor), ... sialic acid binding Ig-like lectin 1, sialoadhesin 15.7 27.1 CCL2 216598_s_at chemokine (C-C motif) ligand 2 15.1 13.4 RSAD2 213797_at radical S-adenosyl methionine domain containing 2 1...

Ngày tải lên: 18/06/2014, 15:20

... ELIS- POT, intra-cellular cytokine staining and major histocom- patiblity multimer staining [45]. Understanding the cryobiology principles that explain cellular function after preservation is becoming ... Foster M, Martin B, Wang E, Smith K, Marin- cola FM: Forecasting the cytokine storm following systemic interleukin-2 administration. J Transl Med 2004, 2:17. 115. Rossi L, Martin B, Hortin G...

Ngày tải lên: 18/06/2014, 15:20

... reducing their number or inhibiting their effector functions intuitively has the potential of increasing the efficacy of anti-tumour immunity. While increasing pre- clinical data support this hypothesis, ... unan- swered issues in this emerging basic and clinical research area in animal models and man toward delineating, e.g., the relative effects of T cells and depletion of Tregs. In t...

Ngày tải lên: 18/06/2014, 15:20

... for biospecimens is resulting in the transformation of biobanking from an immature 'cottage industry' con- ducted by individuals, into a complex institutional activ- ity [5,6]. Biobanking has expanded ... complications inherent in imposing complex research collection protocols on the routine workflow of distinct clinical organizations. These issues also relate to the difficulty...

Ngày tải lên: 18/06/2014, 15:20

... surfaces (e.g., skin, lining of the intestine) against bacteria, and plays a critical role in chronic intestinal inflammation [24,25]. The unchanged IL-17 and IL-23 levels in CFS noted in this study ... evaluation tool in Clinical Med- icine. Clin Chem 1993, 39:561-577. 23. Waldmann TA: The biology of interleukin-2 and interleukin- 15: implications for cancer therapy and vaccine desig...

Ngày tải lên: 18/06/2014, 15:20

... regulating the innate and adap- tive immune systems. Cytokines are thus upregulated in the brain in a variety of diseases, including stroke. In the brain, cytokines are expressed not only in the ... area of research in translational medicine. Cytokines and brain inflammation Cytokines are a group of small glycoproteins that are pro- duced in response to an antigen and were origina...

Ngày tải lên: 18/06/2014, 15:20

... Exp Med 1989, 170:827-845. 42. Kubin M, Kamoun M, Trinchieri G: Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. ... circulating APC populations. Cytokine production in VK3-20-loaded PBMCs In order to evaluate the impact of the VK3-20 protein stimulation on the production of cytokines involved in Table 1 C...

Ngày tải lên: 18/06/2014, 16:20