... Sigalotti et al., Epigenetics of human cutaneous mela-noma: setting the stage for new therapeutic strategies Journal of Transla-tional Medicine 2010, 8:56Sigalotti et al. Journal of Translational ... medium, provided the original work is properly cited.Review Epigenetics of human cutaneous melanoma: setting the stage for new therapeutic strategiesLuca Sigalotti*1, Alessia Covre1,2, ... impairedgrowth of CM cells in vivo, suggesting for the potentialclinical effectiveness of this therapeutic association[39,110]. Recent data, however, showed that the expres-sion of PRAME may prevent the...