Báo cáo hóa học: " Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cynomolgus monkeys'''''''' pot

... cited. Research Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cynomolgus monkeys Yulia ... Vugmeyster et al., Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL- 21R...

Ngày tải lên: 18/06/2014, 16:20

... threshold segmentation and gating. Collagen IV and RECA-1 posi- tive profiles were selected as above. The total number of each labelled profile and the nu mber of co llagen IV and RECA-1 profiles that colocalized ... section images. Collagen IV and RECA-1 positive profile area fraction 10-12 fields per brain section we re selected at random and analyzed f or the number...

Ngày tải lên: 19/06/2014, 22:20

... DNA from PBMC of 2 healthy donors with high and low number of KRECs and TRECs was serially diluted into DNA of a human lymphoblastoid cell line to obtain final concen- trations of normal lymphocyte ... EA: Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferation...

Ngày tải lên: 18/06/2014, 16:20

... conversations with husbands and other family members were necessary to dispel doubts about the protection of privacy and the purely scientific nature of the investigation. Due to low levels of literacy and poor ... impact of socio- economic and psychological factors on sleep in relation to gender differences has received little attention. A recent study found poor sleep...

Ngày tải lên: 18/06/2014, 19:20

... deprivation, health deprivation and disability, education, skills and training deprivation, barriers to housing and services, living environment deprivation and crime) into a single deprivation rank. Based ... Medical Ethics Committee, the Research and Development Panel of the Bedfordshire Heartlands Primary Care Trust and the Research and Development Directorate of the Un...

Ngày tải lên: 18/06/2014, 22:20

... reported by many laboratories to activate an inflammatory phenotype in microglia, including the elevation of phagocytic activity, cytokine expression, and production of NO and reactive oxygen species ... a relatively minor contribution to neuropathology compared to the potent synergistic activation of NMDA receptors by D-ser- ine and glutamate. A role for excitotoxicity in...

Ngày tải lên: 19/06/2014, 22:20

... neu- rodegenerative disease characterized by selective loss of upper and lower motor neurons. Loss of motor neurons results in muscle paralysis and ultimately death due to res- piratory failure. 5–10% of ... targets of this toxicity? Several studies have shown that expression of mutant SOD1 limited to motor neu- rons is insufficient to cause motor neuron degeneration [8,9]...

Ngày tải lên: 19/06/2014, 22:20

... across laboratories and over time [16]. The lack of standard controls for each parameter examined in flow cytometry limits the ability of the assay to be used in a quantitative manner and at best ... ability to activate leukocytes, to stimulate cytokine and proteolytic enzyme production, to mediate angiogenesis, and may be involved in cell prolif- eration and death. [1]...

Ngày tải lên: 18/06/2014, 15:20

... positive p21/WAF1 expression or /and negative MDM2 expression in HCC was a predictor of better survival of patients after tumor resection (P < 0.05). Conclusions: The proteins p53, p21/WAF1, and ... reported to be mutated in 24-69% of HCCs. Mutations of p53 result in unregulated replication of defective DNA, Table 1: Correlation among p53, p21/WAF1, and MDM2 expression i...

Ngày tải lên: 18/06/2014, 15:20

... development of a UC activity index. Symptoms domains that are frequent and responsive to change Thirteen of the 28 symptom domains fulfilled the criteria of a frequent and responsive symptom domain, ... representative example of a symptom domain that fulfilled our criteria of an frequent and responsive symptom domain (frequently present and responsive to change). Infreq...

Ngày tải lên: 18/06/2014, 19:20