... cellactivity of several LOX inhibitors, including aesculetin (anonselective LOX inhibitor), MK886 (an inhibitor of the5-LOX-activating protein), zileuton (a 5-LOX inhibitor),baicalein (a 12/15-LOX inhibitor), ... pro-mote apoptosis. In fact, ROS-induced oxidative stress and cell death play important roles in the efficacy of manyantineoplastic agents [13,14].To investigate whether oxidative stress is involved ... article as: Wei et al., Oxidative stress in NSC-741909-induced apop-tosis of cancer cells Journal of Translational Medicine 2010, 8:37Wei et al. Journal of Translational Medicine 2010, 8:37http://www.translational-medicine.com/content/8/1/37Page...