Báo cáo hóa học: " miR-17-92 expression in differentiated T cells - implications for cancer immunotherapy" docx

... hypothesize that STAT6-regulated miR-1 7-9 2 may contribute to the pro- motion of type-1 T cell functions. Our findings indicate that the tumor-bearing host down-regulates miR-1 7-9 2 in T cells (Fig. ... 4). Interestingly, not only a re STAT6 -/ - T cells resistant to tumor-induced inhibition of miR-1 7-5 p, but CD8 + T cells in tumor bearing STAT6 -/ -...

Ngày tải lên: 18/06/2014, 16:20

... usually incubated with granulocyte-macrophage colony-stimu- lating factor (GM-CSF) and interleukin-4 (IL-4). Because mature DCs (mDCs) are superior to iDCs for the stimu- lation of cytotoxic T- cells, ... and participated in writing the manuscript. THH participated in the design of the study, performed experiments, analyzed the data and participated in writing the manuscript. JR par...

Ngày tải lên: 18/06/2014, 16:20

... 6B). These data further indicate that NSC-741909-induced generation of ROS may con- tribute to the sustained activation of JNK in oncrasin- sensitive cells, which in turn, is critical for NSC-74190 9- mediated ... with their viability set at 100%. Each data point represents the mean ± SD of three independent ex- periments. NAC, N-acetylcysteine; L-NAME, Nω-nitro-L-arginine meth- yl...

Ngày tải lên: 18/06/2014, 16:20

... POS tagging. 4.1 Practical Concerns There are at least two practical concerns in Chi- nese POS tagging. First, we want to obtain in- formation on the distribution of word uses. It may defeat the ... should be captured as early as the tagging begins. So we attempted to resolve the conflict between theoretical and prac- tical concerns via the design of the tagset. In that case the final l...

Ngày tải lên: 08/03/2014, 21:20

... 1.9 -2 .1 -1 .1 -1 .7 -1 .7 -1 .7 -1 .7 cyclin-dependent kinase inhibitor 1C (p57, Kip2) EIF3EIP -2 .0 -1 .6 -2 .0 -1 .8 -1 .6 -1 .6 -1 .7 eukaryotic translation initiation factor 3, subunit E interacting ... 3'-phosphoadenosine 5'-phosphosulfate synthase 2 PID1 -2 .0 -1 .8 -2 .3 -1 .8 -1 .8 -1 .9 -1 .9 phosphotyrosine int...

Ngày tải lên: 18/06/2014, 15:20

... the CTLs exerted significant cytotoxic activity against AMACR- expressing prostate cancer cells in the context of HLA-A24, indicating that AMACR-derived peptides might be useful as prostate cancer ... vaccines for HLA-A24-positive/AMACR- expressing prostate cancer patients. We demonstrated HLA-A24-restricted CTL responses against AMACR- derived peptides for the first time. Inter...

Ngày tải lên: 18/06/2014, 15:20

... 5¢-VIC-CAG TACCTTCCAGCAGATGTGGATCGC-TAMRA-3¢,5 - FAM-CCAGCTTACTTACTTCAATGATGCTCAAAGG C-TAMRA-3¢,5¢-FAM-CTATGCAAGGTCTCAGTCAG GCTCGGC-TAMRA-3¢,5¢-FAM-ATGCTAATGTGGC TCCAGTTTGCCTCT-TAMRA-3¢,5¢-FAM-TCCACTCT CTTTTGAGCCATCCAATGC-TAMRA-3¢,5¢-FAM-AA CGACTTGCTTTTGCTCTTCTCTCGC-TAMRA-3¢ and 5¢-FAM-ATTATAACCCGGTCGTATCTCACGGC-TAM RA-3¢, ... 5¢-AAGTCGT TGCACCTCCTGAGA-3¢,5¢-TCAAGGACGCTGTTGT CACTGT-3¢,5¢-A...

Ngày tải lên: 07/03/2014, 21:20

... CCAAGGGTGGTGGCTGTCCCTC Exon 3 Promoter A p6 TGTCCCTGCTAGTTGTCATTTGG Intron 2 Promoter A p7 ACGACCACTTTGTCAAGCTCATT GAPDH p8 TGAGGTCCACCACCCTGTTG GAPDH p9 TCCTGAAACGCCTTCGGAAGAG E-selectin p10 CCATTGGGTTGAAGGCATTCG ... a1,3GalT-5¢B and E p15 ACTTCTGAAGCCTAAAGGATGCGA Exon 2 a1,3GalT-5¢-C p16 AGGCAGGGCTGGGAGGAA Exon 3 a1,3GalT-5¢-C p17 TTGCTGTCGGAAGATACATTGAG Exon 8 a1,3GalT-coding region p18 CT...

Ngày tải lên: 08/03/2014, 16:20

... expression was also detected in the anterior part of the brain and weaker expression was detected in the posterior section, indi- cating that both genes exhibit a spatial-specific pattern of expression. ... prominent in PTTH- producing cells (PTPCs). These results provide an insight into ecdysone receptor function in the brain during larval-pupal-adult development. Results Expr...

Ngày tải lên: 16/03/2014, 13:20

... hematoxylin-eosin stains and confirmed by immunohistochemical staining look- ing for pan-cytokeratin, cytokeratin 5 and 7, chrom- ogranin A, synaptophysin and tissue-transcripion-factor- 1. For ... previously treated for their cancer using platinum-based chemother- apy. Nevertheless, the presented genes for distinction seem to maintain their value, independent from whether or not th...

Ngày tải lên: 18/06/2014, 15:20