báo cáo hóa học:" Activation of human B cells by the agonist CD40 antibody CP-870,893 and augmentation with simultaneous toll-like receptor 9 stimulation" doc
báo cáo hóa học:" Activation of human B cells by the agonist CD40 antibody CP-870,893 and augmentation with simultaneous toll-like receptor 9 stimulation" doc
... Incubation with CP-870, 893 activated B cells, including both memory and naïve B cells, as demonstrated by upregulation of < /b> CD86, CD70, CD40, and MHC class I and II. CP-870, 893 - activated B cells ... including both memory and naïve B cells asdefined by the presence or absence of < /b> CD27 expression.We studied the effect of < /b> CP-870, 893 on B cell activation< /b> and B cell stimulation of < /b> T cells, and we ... Clinically, for patientsreceiving CP-870, 893 , there may be a link between the ability of < /b> CP-870, 893 to activate B cells and the rapid (buttransient) depletion of < /b> CD 19+ B cells from circulationafter...
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Báo cáo hóa học: " Epigenetics of human cutaneous melanoma: setting the stage for new therapeutic strategies" pot
... an increased recognition of < /b> CM cells by antigen-spe-cific CTL [90 ,95 -97 ]. The ability of < /b> 5-AZA-CdR to re-establish the expression of < /b> different molecules required by CM cells to undergo immune-triggered ... [68].As suggested by the case of < /b> let- 7b, a peculiar behaviour of < /b> miRNA deregulation is that the specific alteration of < /b> asingle miRNA species may impact the biology of < /b> CM cells by concurrently ... of < /b> the target cell during the S-phase of < /b> the cellcycle. Their methylation by DNMT results in a stablecovalent bond between the modified DNA and the enzyme, which is irreversibly inactivated and...
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báo cáo hóa học: " Inhibition of microglial inflammatory responses by norepinephrine: effects on nitric oxide and interleukin-1β production" pdf
... mediated by β2-ARs and may involve cAMP The inhibition of < /b> nitrite accumulation by NE was mim-icked by the β-AR agonist isoproterenol used between 0.1 and 10 µM (Figure 4A), and by the cAMP ... activa-tion of < /b> CREB proteins which may be inhibitory [8]; and inmacrophages may include activation < /b> of < /b> other kinasesInhibitory Effects of < /b> NE are mediated by β-ARs and replicated by cAMPFigure 4Inhibitory ... Spontaneous induc-tion of < /b> nitric oxide- and prostaglandin E2-release by hypoxicastroglial cells is modulated by interleukin 1 beta. Biochem Bio-phys Res Commun 199 7, 238 :91 6 -91 9.62. Hu S, Ali H,...
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báo cáo hóa học: " Inhibition of NF-κB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia" docx
... is important for the induction of < /b> iNOS in glial cells [31], the effect of < /b> BW -B 70C on the activation < /b> of < /b> NF- B was examined in BV2 cells. BW -B 70C inhibited the LPS-mediated NF- B- dependent luciferase ... confirm further the inhibition of < /b> NF- B by BW -B 70C,we examined the effect of < /b> BW -B 70C on nuclear transloca-tion of < /b> p50/p65 complex in LPS-treated primary micro-glial cells. LPS stimulated the nuclear ... translocation of < /b> p65 and p50 subunits to the nucleus, and the translocationwas prevented by BW -B 70C treatment (Fig. 5B C). The observation was confirmed by immunocytochemicalanalysis (Fig. 5D). These...
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báo cáo hóa học:" Chemomodulation of human dendritic cell function by antineoplastic agents in low noncytotoxic concentrations" pdf
... mice bearing lung cancer and treated with DC vaccines [28]. Given the fact that DC vac-cines combined with chemotherapy show therapeutic fea-sibility [ 29] and are highly applicable for human< /b> treatment ... and vinblastine on maturation and activation < /b> of < /b> human < /b> DCsadditionally supports the feasibility of < /b> adjuvant chemo-modulation or chemo-immunotherapy, since these drugswere able to increase the ... concentrations of < /b> eight chemo-therapeutic agents for human < /b> DCs. Cells were treated with a range of < /b> concentrations of < /b> cytotoxic agents (0–100 nM) and the levels of < /b> apoptosis were assessed by Annexin V/PIbinding...
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báo cáo hóa học: " Mechanisms of human cerebellar dysmetria: experimental evidence and current conceptual bases" potx
... [18]. The excitation of < /b> Purkinje neurons isbalanced by the activity of < /b> inhibitory interneuronslocated in the molecular (basket cells, stellate cells) and granular layers of < /b> the cortex (Golgi cells ... phase of < /b> the burst in the ECR, the second phase of < /b> the bur st in the ECR, and the second burst in the FCR, respectively. AGO1 and ANTA2are well demarcated in bottom left panel, unlike in the rig ... S: The mechani sm of < /b> cerebellar hypotonia. Brain 196 9, 92 :621–638. 49. Oulad Ben Taib N, Laute MA, Pandolfo M and Manto MU:Interactio n between repetitive stimulation of < /b> the sciaticnerve and...
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báo cáo hóa học: " Activation of α7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E2 in rat microglial cultures" pdf
... underly-ing the increased synthesis of < /b> PGE2 induced by α7 subunitstimulation by measuring by RT-PCR the levels of < /b> COX-2mRNA. COX-2 is the enzyme responsible for the firstcommitted step in prostaglandin ... from both microglial cells and PC12 cells, used as a positive control (Fig. 2A). The expression of < /b> the receptor was confirmed by labeling microglial cells with FITC-labeleled-α-bungarotoxin (α-Bgtx), ... the stimulation of < /b> α7 nicotinic receptor by the specific agonist nicotine could affect the functional state of < /b> activated microglia by promoting and/ or inhibiting the release of < /b> other important...
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báo cáo hóa học: " Activation of microglial NADPH oxidase is synergistic with glial iNOS expression in inducing neuronal death: a dual-key mechanism of inflammatory neurodegeneration" docx
... FeTPPS) but not by a blocker of < /b> the NMDA receptor (10 µM MK-801). Nitrite and nitrate levels were not affected by the presence of < /b> PMA or apocynin but were significantly reduced by 1400W (b) . Statistical ... 4).LPS/IFN-γ/BzATP induced neuronal death was blocked by inhibitors of < /b> iNOS, NADPH oxidase and a peroxynitritescavenger, but not by the NMDA receptor blocker. Activation < /b> of < /b> NADPH oxidase in the presence ... neuronaldeath occurred (Figure: 5a, b) and was blocked by inhibi-tors of < /b> iNOS, NADPH oxidase, a peroxynitrite scavenger and a blocker of < /b> the NMDA receptor. Treatment with IL-1β or AA alone did not...
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báo cáo hóa học: " Activation of retinal microglia rather than microglial cell density correlates with retinal neovascularization in the mouse model of oxygen-induced retinopathy" ppt
... zone and the peripheral zone. (B) Cryosection of < /b> the eye showing the superficial layer (s) and the deep layer (d) of < /b> microglia (GFP, green). The nuclei (DAPI, blue) of < /b> the retinal ganglion cells ... adjacent to the endothelial cells of < /b> the vascular tufts.Hyalocytes were identified by their position above the inner retinal vascular layer (i. e. in the vitreous),their round cell body without ... while obser-ving them in the microscope at high resolution (40×objective). The lay ers could be clearly separated by focussing. Activated microglial cells were recognized by their short and thick...
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Tài liệu Báo cáo khoa học: Regulation of cathepsin B activity by 2A2 monoclonal antibody docx
... frag-ment with the cathepsin B/ cystatin C complex The effect of < /b> 2A2 mAb and its Fab fragment on the stability of < /b> the complex formed between recombinant human < /b> cathepsin B and recombinant human < /b> cystatin ... concentrations of < /b> 2A2mAb or its Fab fragment caused a decrease in the level of < /b> the cathepsin B ⁄ cystatin C complex, whereas the level of < /b> the complex formed between cathepsin B and the antibody or its Fab ... followed by the binding of < /b> another two loops of < /b> the inhibitor [24].Besides protein inhibitors, the irreversible epoxysucci-nyl inhibitor E-64 and other cathepsin B specific epox-ide containing synthetic...
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Từ khóa: báo cáo khoa họcbáo cáo môn học hóa dầubáo cáo trường học văn hóa năm 2012báo cáo trường học văn hóaquảng cáo trên báo giấy hoa học tròNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANPhát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngThơ nôm tứ tuyệt trào phúng hồ xuân hươngTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Kiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Quản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)