báo cáo hóa học:" Activation of human B cells by the agonist CD40 antibody CP-870,893 and augmentation with simultaneous toll-like receptor 9 stimulation" doc

... Incubation with CP-870, 893 activated B cells, including both memory and naïve B cells, as demonstrated by upregulation of < /b> CD86, CD70, CD40, and MHC class I and II. CP-870, 893 - activated B cells ... including both memory and naïve B cells as defined by the presence or absence of < /b> CD27 expression. We studied the effect of < /b> CP-870, 893...

Ngày tải lên: 18/06/2014, 15:20

... an increased recognition of < /b> CM cells by antigen-spe- cific CTL [90 ,95 -97 ]. The ability of < /b> 5-AZA-CdR to re- establish the expression of < /b> different molecules required by CM cells to undergo immune-triggered ... [68]. As suggested by the case of < /b> let- 7b, a peculiar behaviour of < /b> miRNA deregulation is that the specific alteration of < /b> a...

Ngày tải lên: 18/06/2014, 16:20

... mediated by β 2-ARs and may involve cAMP The inhibition of < /b> nitrite accumulation by NE was mim- icked by the β-AR agonist isoproterenol used between 0.1 and 10 µM (Figure 4A), and by the cAMP ... activa- tion of < /b> CREB proteins which may be inhibitory [8]; and in macrophages may include activation < /b> of < /b> other kinases Inhibitory Effects of < /b>...

Ngày tải lên: 19/06/2014, 22:20

... is important for the induction of < /b> iNOS in glial cells [31], the effect of < /b> BW -B 70C on the activation < /b> of < /b> NF- B was examined in BV2 cells. BW -B 70C inhibited the LPS-mediated NF- B- dependent luciferase ... confirm further the inhibition of < /b> NF- B by BW -B 70C, we examined the effect of < /b> BW -B 70C on nuclear transloca- tion of <...

Ngày tải lên: 19/06/2014, 22:20

... mice bearing lung cancer and treated with DC vaccines [28]. Given the fact that DC vac- cines combined with chemotherapy show therapeutic fea- sibility [ 29] and are highly applicable for human < /b> treatment ... and vinblastine on maturation and activation < /b> of < /b> human < /b> DCs additionally supports the feasibility of < /b> adjuvant chemo- modulation or chemo-i...

Ngày tải lên: 18/06/2014, 15:20

... [18]. The excitation of < /b> Purkinje neurons is balanced by the activity of < /b> inhibitory interneurons located in the molecular (basket cells, stellate cells) and granular layers of < /b> the cortex (Golgi cells ... phase of < /b> the burst in the ECR, the second phase of < /b> the bur st in the ECR, and the second burst in the FCR, respectively. AGO1...

Ngày tải lên: 19/06/2014, 08:20

... underly- ing the increased synthesis of < /b> PGE 2 induced by α7 subunit stimulation by measuring by RT-PCR the levels of < /b> COX-2 mRNA. COX-2 is the enzyme responsible for the first committed step in prostaglandin ... from both microglial cells and PC12 cells, used as a positive control (Fig. 2A). The expression of < /b> the receptor was confirmed by label...

Ngày tải lên: 19/06/2014, 22:20

... FeTPPS) but not by a blocker of < /b> the NMDA receptor (10 µM MK-801). Nitrite and nitrate levels were not affected by the presence of < /b> PMA or apocynin but were significantly reduced by 1400W (b) . Statistical ... 4). LPS/IFN-γ/BzATP induced neuronal death was blocked by inhibitors of < /b> iNOS, NADPH oxidase and a peroxynitrite scavenger, but not by the NMDA...

Ngày tải lên: 19/06/2014, 22:20

... zone and the peripheral zone. (B) Cryosection of < /b> the eye showing the superficial layer (s) and the deep layer (d) of < /b> microglia (GFP, green). The nuclei (DAPI, blue) of < /b> the retinal ganglion cells ... adjacent to the endothelial cells of < /b> the vascular tufts. Hyalocytes were identified by their position above the inner retinal vascular layer...

Ngày tải lên: 19/06/2014, 22:20

... frag- ment with the cathepsin B/ cystatin C complex The effect of < /b> 2A2 mAb and its Fab fragment on the stability of < /b> the complex formed between recombinant human < /b> cathepsin B and recombinant human < /b> cystatin ... concentrations of < /b> 2A2 mAb or its Fab fragment caused a decrease in the level of < /b> the cathepsin B ⁄ cystatin C complex, whe...

Ngày tải lên: 18/02/2014, 11:20