... interleukin-1 alpha(IL-1 alpha), tumor necrosis factor-alpha (TNF-alpha),interleukin-2 (IL-2), and interferon-gamma (IFN-gamma)ataproteinandgenelevelinPBMCwasincreased after He-Ne irra diation at 18.9 ... therapy accelerates collateral circulation and enhances microcirculation. Photomed Laser Surg 2005, 23:289-294.115. Taguchi A, Soma T, Tanaka H, Kanda T, Nishimura H, Yoshikawa H,Tsukamoto Y, ... candi-dates, ENT-111, and ENT-894. As a commercially-oriented organization, we needed to develop a therapeu-tic candidate that not only has a great potential for effi-cacy, but also can be easily...