báo cáo hóa học:" Immunological considerations of modern animal models of malignant primary brain tumors" doc

... CentralPage 1 of 9(page number not for citation purposes)Journal of Translational MedicineOpen AccessReview Immunological considerations of modern animal models of malignant primary brain tumorsMichael ... functions.Specific to the current discussion of the immune system,Table 1: A summary of existing animal models of brain tumorsTumorigenesis Method Technique Tumor Animal RefImplantation 9 L Gliosarcoma ... influence of pre-clinical therapeutics testing warrantsfurther attention.The Potential Promise of Immunotherapy for Primary Brain Tumors Primary central nervous system (CNS) malignancies,though of...

báo cáo hóa học:" More insights into the immunosuppressive potential of tumor exosomes" pptx

... Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9protein. J Exp Med 2008, 205:2235-2249.Journal of Translational ... http://www.translational-medicine.com/content/6/1/63Page 3 of 4(page number not for citation purposes)unpublished, [32]]. Benefits from modulation of exo-some secretion could also come from qualitatively shap-ing protein composition of secreted ... withdrugs altering biological features of tumor vesicles, suchin the case of curcumin, a natural polyphenol which hasbeen shown to reduce immunosuppressive functions of breast carcinoma-secreted exosomes...

báo cáo hóa học:" An intron 9 containing splice variant of PAX2" pptx

... regulator of WT1. Recently, WNT5A [16] andhuman beta-defensin-1 [17] were identified as PAX2 tar-gets.Four isoforms of PAX2 are described so far. They are prod-ucts of alternative splicing of exon ... electrophoresis of the PAX2 exon 10 RT-PCR products from the mRNA of the lymphoma cell lines. All lymphoma cell lines: band of 339 bp of varying intensity. KM-H2, EHEB, L540 and DG75: band of the expected ... the growth andsurvival of cancer cells. Due to alternative splicing of exon 6, exon 10 and exon 12 four isoforms of PAX2 are described so far.Methods: The expression of an intron 9 containing...

báo cáo hóa học:" Human fallopian tube: a new source of multipotent adult mesenchymal stem cells discarded in surgical procedures" potx

... addition, the majority of cells expressed high levels of adhesion markers (CD29,CD44 and CD90) and MSCs markers (CD13, CD73, SH2,Morphology of adherent cells when isolated from hFTs (primary cultures)Figure ... mayrepresent a new potential source of pluripotent cells forregenerative medicine. The identification of niches of tis-sue-specific stem cells capable of replacing damaged dif-ferentiated ... character-ization of potential sources of adult stem cells [7,10,12-15], the aim of this study was to isolate, expand, charac-terize and assess the differentiation potential of MSCsfrom hFTs.MethodsHuman...

báo cáo hóa học:" Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment" pot

... mechanisms of action and effects of both Andro and LA for treatment of diabetes, we con-ducted experiments to evaluate the efficacy and possiblemechanism(s) of action of a conjugate of Andro ... serum, 2 mM glutamine, 100 units/ml of penicil-lin, and 100 μg/ml of streptomycin.Structures of Andro, LA and AL-1Figure 1Structures of Andro, LA and AL-1.Journal of Translational Medicine 2009, ... plasma membrane of isolatedsoleus muscles of diabetic mice was measured by westernblot analysis. The protein level of GLUT4 in the soleusmuscles of diabetic mice was only 49.5% that of the non-diabetic...

báo cáo hóa học:" Phase I/II open-label study of the biologic effects of the interleukin-2 immunocytokine EMD 273063 (hu14.18-IL2) in patients with metastatic malignant melanoma" docx

... concentration-time profiles of EMD 273063Figure 1Mean serum concentration-time profiles of EMD 273063. Mean serum concentration-time profiles after daily 4-h infu-sions of EMD 273063, days 1–3 ... and an underlyingresponse rate of 15%.To gain insight on the effects of the immunocytokine onthe immune system, we measured serum levels of Table 4: Analysis of immunological parameters in tumor ... or absence of macroscopic tumor does not influencethe clearance of EMD 273063 [7]. In our study, the safetyprofile of EMD 273063 was consistent with the expectedIL2 side effect profile as reported...

báo cáo hóa học:" A practical approach for the validation of sterility, endotoxin and potency testing of bone marrow mononucleated cells used in cardiac regeneration in compliance with good manufacturing practice" docx

... inoculation of TSBand FTM media with 1% of the total volume of the prod-uct under validation as stated in European Pharmaco-poeia (2.6.27). For the latter, 500 μl of whole blood and100 μl of the ... con-taining 500 μl of Endocult Basal Medium supplementedwith Endocult Single Quots (Stemcells Technologies, Van-couver, Canada) and 20% fetal calf serum (Figure 1). After24 hours of incubation ... by an enzyme produced in the reaction of the lysate in the presence of endotoxin. The system con-sists of LAL reagents and endotoxin controls in the form of a single-use polystyrene cartridges....

Báo cáo hóa học: " Endotoxin and CD14 in the progression of biliary atresia" ppt

... of 1.7-2.0. A total of 2 μgofRNA was added to 0.1 μgofoligo-d(T)15following theprotocol for SuperScr ipIIRT (Inv itrogen, Carlsbad, CA).Quantitative PCR was performed in a final volume of 20-μl ... 6).All animal experiments were performed in accordancewith and approved by the Animal Care and Use Commit-tee of Chang Gung Memorial Hospital at Ka ohsiung.Blood samples were collected at time of ... BA.Although studies of liver injury should take intoaccount the relative contributions of CD14 in Kupffercells and hepatocytes, few reports document the propor-tional change of mCD14 and sCD14...

báo cáo hóa học: " Thai SF-36 health survey: tests of data quality, scaling assumptions, reliability and validity in healthy men and women" pdf

... qualityThe number of completed items, the percent of missingdata in every item and the frequency distribution of indi-vidual items were determined.Ordering of levels of healthThe ordering of item means ... Chaithiraphan S:Reliability of Thai version of SF-36 questionnaire for the eval-uation of quality of life in cardiac patients. Journal of the MedicalAssociation of Thailand 2000, 83:S130-136.2. ... 83:S130-136.2. Kongsakon R: The functioning and quality of life of depressivepatients with 12 weeks of psychiatric care. Journal of the MedicalAssociation of Thailand 2005, 88:1261-1266.3. van Griensven...

báo cáo hóa học: " Cognitive interviewing methodology in the development of a pediatric item bank: a patient reported outcomes measurement information system (PROMIS) study" docx

... DeWalt3Address: 1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 2Department of Pediatrics, College of Medicine, Department of Landscape Architecture ... ration-ale of the directions, the meaning of the items, the appro-priateness of the response choices, and overall commentson the relevance and complexity of the questionnaire[12,13].The primary ... friends. Some of the children used words like "trust" or "count on" to interpret the question. Two out of six of the children said they weren't sure of the meaning of "rely."I...

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