báo cáo hóa học:" Phase I/II open-label study of the biologic effects of the interleukin-2 immunocytokine EMD 273063 (hu14 18-IL2) in patients with metastatic malignant melanoma" docx

... biologic effects of the interleukin-2 immunocytokine EMD 273063 (hu14. 18-IL2) in patients with metastatic malignant melanoma Antoni Ribas 1 , John M Kirkwood 2 , Michael B Atkins 3 , Theresa ... response. The main finding of this study was an increase in intratumoral CD8+ CTL with possible increased expression of CD3zeta and granzyme B after adminis...

Ngày tải lên: 18/06/2014, 15:20

... 0.0206). Discussion This study established the safety and feasibility of com- bining vaccination with MVA expressing 5T4 and high- dose IL-2 in patients with metastatic RCC. The trial was Table 3: ... Yang JC, White DE, Steinberg SM: Durability of complete responses in patients with metastatic cancer treated with high-dose interleukin-2: identification of the...

Ngày tải lên: 18/06/2014, 15:20

... were induced with the gp100 -in4 stimulation on the PBMCs taken from the patients (P1, P2, P3, and P4) after the vaccination. The PBMCs of P1 showed an incremental increase in the frequency of induced ... IFN-g-producing cells in association with the number of the vaccinations. In P2, a significant increase of the frequency of induc- tion of IFN-g-pro...

Ngày tải lên: 18/06/2014, 16:20

... was involved in the tumor sample collection. AVH and MR were involved in the statistical analysis of the data. JN, GG and MS were involved in the data collection of the patients, and in the review ... removed from the training set. The other samples are reduced to those 50 genes with the highest signal-to-noise ratio, which are used as a training set in a tr...

Ngày tải lên: 18/06/2014, 15:20

... anti-inflammatory property targeting at different levels of TNF-α activity. The anti-inflammatory role of ginseng may be due to the combined effects of ginsenosides, contributing in part to the ... present in significant concentrations may modulate the activity of the ginsenosides. We then investigated the combinatorial effect of the nine ginsenosides on TNF-α in...

Ngày tải lên: 18/06/2014, 15:20

... data was obtained using the summary PROF, PROFAD and SSI indices. Principal component analysis was used to investigate the internal structure of the PROFAD-SSI. Facet scores rather than individual ... design of the study. FV participated in the design of the study. NM participated in the design of the methodology, managed data collection, conducted some of the...

Ngày tải lên: 18/06/2014, 18:20

... health-related quality of life. HRQOL is defined as the perception of overall satisfaction with life and involves the measurement of functional sta- tus in the domains of physical, cognitive, ... rate during the submaximal graded exercise test, or were missing any data required for the analysis. Any participant who reported smoking on the morning of the HFA was exc...

Ngày tải lên: 18/06/2014, 18:20

... erval, by analogy to theconstraintinducedbyametronome;2)thatTW may increase the local dynamic stability of walking, due to the diminution of degrees of freedom in the more constrained artificial e ... exponent requires intensive computing power, 7 min of the 10 min walking test (from 1.5 to 8.5 min.) was selected and the raw data were down-sampled to 100 Hz. The determin...

Ngày tải lên: 19/06/2014, 08:20

... the stance phase (the phase in which the foot is on the ground). Others use the energy from the bending of the shoe sole. In both cases, the device aims to use the energy that would otherwise have ... However, there were certain d rawbacks associated with this device in that it used only a small part of the motion of the knee (end of the swing phase...

Ngày tải lên: 19/06/2014, 08:20

... forward, thereby preventing over-recognition when user is talking to some- one. Plus the direction of the IW is determined by the inclination of the user's face instead of the direction of the user's ... abilities, the proposed system involves the use of face-inclination and mouth-shape information, where the direction of an IW is determined by the in...

Ngày tải lên: 19/06/2014, 08:20