... recognition sequence preventing the binding of transcription factors, or may be a consequence of the binding of methyl-CpG-binding proteins (MBP), which recruit chromatin remodelling co-repressor complexes. ... 5-aza-2'-deoxycy-tidine (5-AZA-CdR) in different CM cell lines, allowingto identify a large number of genes that were potentiallyinactivated by promoter methylation in CM, as furthersupported by preliminary ... modifications of his-tones, and in particular their hypoacetylation, profoundlyinfluence CM cell biology by affecting cell cycle regula-tion, cell signaling, differentiation, DNA repair, apoptosis,invasion...