báo cáo hóa học:" Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis" pot

... GM and TRZ: contrib-uted to study design and concept and writing and editing of the manuscript. VT: contributed to the study design and concept, writing and editing of the manuscript and provided ... manuscript. TZ provided samples,supervised in study design, and was involved in drafting the manuscript. VT carried out the initial conception and design of the study, supervised and assisted in laboratorytechniques, ... 25-hydroxyvitamin D, Vitamin D Binding Protein, and LL-37 Concentrations in Critically Ill Subjects With and Without Sepsis and Healthy Subjects Vitamin D status differed in the critically ill subjects with sepsis,...

báo cáo hóa học:" Static platelet adhesion, flow cytometry and serum TXB2 levels for monitoring platelet inhibiting treatment with ASA and clopidogrel in coronary artery disease: a randomised cross-over study" potx

... ASA and clopidogrel combined compared with either drug alone.Conclusion: The indirect pharmacodynamic measures of the effects of ASA and clopidogrel might be used together with ADP-induced activation ... ristocetin-induced adhesion appears to bedependent on GPIb-IX-V and vWf [23].We found that platelet adhesion to albumin, collagen and fibrinogen induced by ADP was suppressed during treat-ment with ... TXB2 -levels of patients were com-pared to the mean of the two visits for controls included in the present study. ADP-induced platelet adhesion (Fac-tor 1) and ristocetin-induced adhesion...

Báo cáo khoa học: Mitochondrial transcription factor A overexpression and base excision repair deﬁciency in the inner ear of rats with D-galactose-induced aging pdf

... signiﬁcant difference was foundbetween the low-dose and medium-dose groups(P > 0.05).Increased mRNA level of TFAM induced by D- GalTo understand whether increased mtDNA proliferationinduced by d ... partiallyexplain the increased mutation load in the inner ear. In our study, increases in TFAM expression and dele-tion mutation load were demonstrated in the inner ear of d- Gal-treated rats. The replication ... enzymes tested. As compared with the control group, the expression of Pol-c protein in the inner ear was reduced by 1.6-fold, 1.9-fold and 4.8-fold in the low-dose, medium-dose and high-dose groups,respectively....

báo cáo hóa học:" Validation of a flow cytometry based chemokine internalization assay for use in evaluating the pharmacodynamic response to a receptor antagonist" potx

... pla-cebo and 54 dosed) individuals were assessed at all timepoints except day 3. Mean, standard deviation % CV and standard error for the data grouped across all placebos and placebos + pre-dose ... experiments and drafted the manuscript. AL carried out the assay in the clinical trials.MG aided in the design of the experiments and review of the manuscript. All authors read and approved the finalmanuscript.Acknowledgements The ... only 9 of the 54 individualswere sampled at the day 3 time point leading to a poten-tial sampling bias in the data. At all other time points, all108 (54 placebo and 54 dosed) individuals whereassessed...

báo cáo hóa học:" Comprehensive molecular etiology analysis of nonsyndromic hearing impairment from typical areas in China" doc

... par-ticipated in sequence alignment and performed the statis-tical analyses. HY and DH participated in the design of the study. PD conceived the study, participated in its design and coordination, and ... results in a premature stop codon and a truncated Cx31 protein. In addition, 24_49ins26bp and N166S were detected only in patients with hearingimpairment and not in the controls, and they are ... mutation in the presentstudy had a history of aminoglycoside use. Pedigree anal-ysis showed maternally inherited traits, and these patients were diagnosed as having aminoglycoside-induced non-syndromic...

Báo cáo hóa học: " S110, a novel decitabine dinucleotide, increases fetal hemoglobin levels in baboons (P. anubis)" potx

... analysis. DL, YS, and JDinterpreted the data and wrote the manuscript. All authors read and approved the final manuscript.Competing interestsDL, YS, KV, MS, and VB, and JDS have no competing interests. ... S110 into the deoxycytosine analog decitabine that binds and depletes DNA.Conclusion: S110 is rapidly converted into decitabine, hypomethylates DNA, and induce s HbF in cultured humanerythroid ... period.Induction of HbF occurred following admi nistration ofboth S110 and decitabine. Individual differences in max-imal HbF attained were observed between the twobaboons, and decitabine induced...

Báo cáo hóa học: "Quantification of newly produced B and T lymphocytes in untreated chronic lymphocytic leukemia patients" ppt

... diseasestage and the occurrence of infections [3]. Accordingly, in all our patients but one, the IgG and IgA serum levels were within the normal range found in controls, and this was expected, considering ... recruited the patients. MC, CG, CZ and CL performed the laboratory work for this study. LI, MM, LC and GR wrote the manuscript and participated to the discussion. All authors read and approved the finalmanuscript.Competing ... generated during the rear-rangement of IGK chain that remain stably present in the genome and are duplicated during each cell division.Statistical analysisSince data did not follow a Gaussian distribution,...

báo cáo hóa học: " What determines subjective health status in patients with chronic obstructive pulmonary disease: importance of symptoms in subjective health status of COPD patients" pdf

... collected the date,performed statistical analysis and drafted the manuscript.AKW, BRH and AHH participated in the design and revised the manuscript critically. TWL participated in the design, conducted ... deaths, and the associated health costs willincrease during the next decade. In addition to the socialstrain, COPD also influences the patients& apos; symptoms,function, and subjective health status ... status of patients with COPD than demographics, physiological variables, or physical function. These findings should beconsidered in the treatment and care of these patients. Published: 18 December...

báo cáo hóa học: " Additional impact of concomitant hypertension and osteoarthritis on quality of life among patients with type 2 diabetes in primary care in Germany – a cross-sectional survey" doc

... patients with type 2 diabetes in primary care regarding the common comorbid conditions hyperten-sion and osteoarthritis and therefore contributes to a bet-ter understanding of diabetic patients. The ... within further research.Competing interests The authors declare that they have no competing interests.Authors' contributionsAM designed and conducted the study and drafted the manuscript. ... calculate the body mass index (BMI) werecorded height and weight of the patients. We assessed the socioeconomic status (SES) with a non-weightedsocial class index based on the three dimensions educa-tion,...

Báo cáo hóa học: " EQ-5D visual analog scale and utility index values in individuals with diabetes and at risk for diabetes: Findings from the Study to Help Improve Early evaluation and management of risk factors Leading to Diabetes (SHIELD)" potx

... performed the statistical analysis and drafted the manuscript. All authors read and approved the final man-uscript.Acknowledgements The SHIELD Study Group includes the following individuals: Harold ... and associates and Sitoh and colleagues [18,19], an ordinal variable for the EQ- 5D index was created by categorizing the continuousvariable into 4 levels, and an ordered logit regressionmodel ... Barthel Index, and Modified Rankin scale)[25,27,28]. The EQ- 5D has performed equally well whencompared with other generic HRQoL and utility-basedinstruments, including the Health Utilities Index...

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