báo cáo hóa học:" Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma" ppt

... interaction and reported the Kd and Bmax values of sigma-2 receptor lig- ands in models of pancreatic adenocarcinoma. Further- more, we have demonstrated that sigma-2 receptor specific ligands induce ... recently shown that selected sigma-2 ligands are capable of inducing apoptosis in a multitude of human and murine cancer cells lines and in animal mod...

Ngày tải lên: 18/06/2014, 15:20

... IRAK4-kinase-dead knock -in mic e also fail, in vitro and in vivo,toproduce inflammatory cytokines in response to LPS and are pro- tected against LPS-induced sepsis in vivo [1 9,22-24]. There is, however, a resounding ... expression of 567 LPS- responsive genes in human monocytes, including a broad array of genes (pro-inflammatory interleukins, CXC and CC chemokines, and...

Ngày tải lên: 18/06/2014, 16:20

... epithelial survival in the setting of stress. Understanding the molecular structure and function of it and its ligands in the setting of inflammation is critically important in understanding the role of ... bypassing the Golgi [103]. Several S100 proteins bind the tetramerization domain of p53, and some also bind the negative regula- tory domain of p53. Binding of...

Ngày tải lên: 18/06/2014, 15:20

... found integrin alpha 3, integrin beta 2 and intercellular adhesion molecule 1 to be upregulated in adenocarcinomas, while 6 genes, including the desmo- somal cadherins desmoglein 3 and desmocollin ... purposes) nomas of the lung plays a role in the loss of cell to cell contact and tumor spreading. The extracellular cell matrix receptors integrin alpha-3 and integrin beta-2 as...

Ngày tải lên: 18/06/2014, 15:20

... mitotic spindle checkpoint involving chromosome maturation and segregation [13-15]. Two proteins known to bind and initiate activation of Aurora-A are TPX2 [16,17] and Ajuba [13]. Upon binding, TPX2 ... scored on a four level scale (0 = no staining, 1 = weak staining, 2 = moderate staining, 3 = intense staining) by a GU patholo- gist. Results Expression Profiling of Ovarian Cancer P...

Ngày tải lên: 18/06/2014, 15:20

... in cell death in CAVM1 cells. An intriguing mechanism, in this regard, is the presence of scaffolding domain in caveolin- 1 that binds to and inhibits the activity of several signaling proteins ... concentrations of RES induced a marked increase in cell number in sub-G1 and G0/G1 phase, with a corresponding decrease in other phases. Interestingly, concentrations of R...

Ngày tải lên: 18/06/2014, 15:20

... activity of a kinesin inhibitor. Cancer Res 2004, 64:3276-3280. 26. Tao W, South VJ, Diehl RE, Davide JP, Sepp-Lorenzino L, Fraley ME, Arrington KL, Lobell RB: An inhibitor of the kinesin spindle ... Falus A: Autocrine and para- crine regulation by cytokines and growth factors in melanoma. Cytokine 2000, 12:547-554. 33. Nicolini A, Carpi A, Rossi G: Cytokines in breast cancer. Cyt...

Ngày tải lên: 18/06/2014, 15:20

... medicine, defined as "the transfer of new understandings of disease mechanisms gained in the laboratory into the development of new methods for diagnosis, therapy, and prevention and their first ... Medicine Open Access Commentary Translating molecular medicine into clinical tools: doomed to fail by neglecting basic preanalytical principles Klaus Jung* 1,2 , Ferdinando Manne...

Ngày tải lên: 18/06/2014, 15:20

... Comparison of the effects of S110 and decityabine on globin gene expression in cultured human erythroid progenitor cells. A. Effect of decitabine and S110 on expression of g-globin mRNA in cultured ... period. Induction of HbF occurred following admi nistration of both S110 and decitabine. Individual differences in max- imal HbF attained were observed between the two b...

Ngày tải lên: 18/06/2014, 16:20

... us (WS) was involved in an investigation that clearly showed that neu- trophils do not catalyze oxidative phosphorylation and the remaining complexes of the respiratory chain main- tain the mitochondrial ... low and not increased before and 24 h after exercise in the patient group, and not different from the control group, suggest- ing no muscle damage and no major intrinsic a...

Ngày tải lên: 18/06/2014, 16:20