... of scaffolding domain in caveolin-1 that binds to and inhibits the activity of several signalingproteins in vitro and in situ, including the EGF and Neureceptors, Src-family kinases (Src/Fyn), ... trafficking. CAV1 can sup-press epidermal growth factor tyrosine kinase (EGF),extra-cellular signal-regulated kinase (ERK), endothelialnitric-oxide synthase, threonine protein kinase, serineprotein ... ofERK1/2, p38 kinase, or active caspase-3, respectively. As control, total ERK1/2, p38 kinase, and caspase-3 wereanalyzed with the respective specific antibodies followingmanufacturer's instructions...