báo cáo hóa học:" Phase II trial of Modified Vaccinia Ankara (MVA) virus expressing 5T4 and high dose Interleukin-2 (IL-2) in patients with metastatic renal cell carcinoma" pot

... 1 of 11 (page number not for citation purposes) Journal of Translational Medicine Open Access Research Phase II trial of Modified Vaccinia Ankara (MVA) virus expressing 5T4 and high dose Interleukin-2 ... established the safety and feasibility of com- bining vaccination with MVA expressing 5T4 and high- dose IL-2 in patients with metas...

Ngày tải lên: 18/06/2014, 15:20

... loaded cells was measure d by intracellular IFN-g and/ or TNF-a cytokine staining. In 8 of 10 patients the presence of TNF-a and/ or IFN-g pro- ducing WT1 126-134 specific CD3+CD8+ T cells could be induced ... within a phase II vaccination trial and progressed after an initial interval of vaccine efficacy [8]. T cell response to vaccination was analyzed as previously pub...

Ngày tải lên: 18/06/2014, 16:20

... hyperbolic equations and systems in domains with co nical points. These problems with t he Dirichlet boundary conditions were investigated in [3-5] in which the unique existence, the regularity and the asymptotic ... constant independent of u N , f and τ. For the terms III and IV, by the Cauchy inequality, we have III ≤ (μ − ε 2 )ρ 2 m  μ 1 + ε 1 |u N | 2 0,Q τ + m  μ 1...

Ngày tải lên: 21/06/2014, 00:20

... lower disinhibition score, indicating an increase likelihood to overeat in the presence of disinhib- itors. This was an unexpected finding and may indicate that there are still certain triggers ... have been influenced by all study patients participating in an orientation meeting, in addition to meeting with the prin- cipal investigator at the 3 measurement time points. It may b...

Ngày tải lên: 18/06/2014, 19:20

... affects indi- viduals between 0 and 18 years of age and represents from 0.5 to 3.0% of malignant tumors in most populations. In Brazil, the estimated incidence of children with tumors in 2006 ... was defined as individuals who only came to the hospital for the administration of chemotherapy and were being taken care of at home. Most of the patients were in out-pa...

Ngày tải lên: 18/06/2014, 22:20

... establishment of a set of training and validation samples. After a thor- ough analysis of possible training and validation sets, we decided to use 40% of the samples for training, 40% for validation, and ... prediction capability of the methods in the literature, including or not including age and sex, with or without pre-selection of noncorrelated compone nts, using S...

Ngày tải lên: 21/06/2014, 01:20

... extragradient method and viscosity approximation method for finding the common element of the set of fixed points of a nonexpansive mapping, the set of solutions of an equilibrium problem, and the solutions of the ... 2008. 26 X. Qin, S. Y. Cho, and S. M. Kang, “Convergence of an iterative algorithm for systems of variational inequalities and nonexpansive mappings wit...

Ngày tải lên: 21/06/2014, 07:20

... visual inspections are usually a first step when evaluating patients under clinical suspicion of suffering from OSA. Visual examination of patients includes searching for distinctive features of the ... normal and pathological voices as an alternative method of diagnosis is becoming increasingly interesting for researchers in laryngological and speech pathologies in general...

Ngày tải lên: 21/06/2014, 20:20

... Horbach, and R. S. Pellegrini, “Multichannel in- verse filtering of multiexciter distributed mode loudspeaker for wave field synthesis,” in Proceedings of the 112th Conven- tion of the Audio Engineering ... reflections?” in Proceedings of the 116th Conven- tion of the Audio Engineering Society (AES ’04), Berlin, Alle- magne, Germany, March 2004. [20] S. Spors, M. Renk, and R....

Ngày tải lên: 22/06/2014, 23:20

... upon binding with GDP-bound G-protein, whereas an increase in the J-band intensity was elicited upon interaction of Calnuc and GTP-bound G-protein (Fig. 8B). Interestingly, why G-protein binding ... Ca 2+ ‘competes off’ the dye (attenuating both the J-band and the c-band), indicating that the dye binds in the EF-hand motif. Binding of Mg 2+ caused a decrease only in the c-band...

Ngày tải lên: 07/03/2014, 00:20