báo cáo hóa học:" Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells" docx

... Translational Medicine Open Access Research Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells Hemant Sarin* 1,2 , Ariel S Kanevsky 2 , ... less defective BBTB of the smallest gliomas within the size range of brain tumors in our study (Figure 3B). In the case of the largest RG-2 gliomas wit...

Ngày tải lên: 18/06/2014, 15:20

... mixed solution of ammonium hydroxide and hydrogen peroxide for the generation of hydr oxyl groups on NOA63 polymer sur- faces and compared the effectiveness of this method with that of previously ... anodization process, employing 0.3 M of oxalic acid as an electrolyte at an anodization voltage of 40 V. The surface of the AAO nanoholes was then coated with an ether-termi...

Ngày tải lên: 20/06/2014, 23:20

... in interpreting the data (using ABqPCR software). LMD assisted in the retrieval of the FFPE specimens, selection of cases and editing of the manuscript. JMK performed the original clinical evaluation of the ... [72]. We are the first to report the modulation of this miR in the context of melanoma. It is possible that the upregulation of this miR in the adul...

Ngày tải lên: 18/06/2014, 16:20

... Hha I yet these were justified as alternate secondary structures of the hairpin in the flip conformation. The expected fragments for the digestion of the flip and flop conformations of the left ... hairpin, capable of acting as an origin of replication, lacks the arrangement of the specific domains present in the dimer duplex intermediate of MVM, the only act...

Ngày tải lên: 20/06/2014, 04:20

... dis- semination of information to the citizenry of Nigeria has been reported previously.[11,14] The present study fur- ther strengthened the evidence that the mass media is making the desired impact ... that the schizophrenic patients had more misconceptions about the route of transmission of HIV infection than the comparator group. These mis- conceptions may be respon...

Ngày tải lên: 20/06/2014, 08:20

... Immunopathology Ph.D. program of the Uni- versity of Insubria, A. Ventura was in the Vaccine Prevention PhD program of the University of Genoa and is the recipient of a FIRC fellowship. M. Pin- ter ... respon- sible for the resistance of tumors to anti-VEGF therapy [33], largely via production of the angiogenic VEGF- related factor Bv8 [36]. Angiostatin clearly influ...

Ngày tải lên: 18/06/2014, 15:20

... capture into the charged dot may be realized either via tunneling through the barrier or via thermal excitation above the barrier. The relative probability of these two processes depends on the char- acteristic ... In the case o f the intra-dot doping, the dot charge n q is equal to the dot population n reduced by the number of dopants p in the dot, i.e., n q =...

Ngày tải lên: 20/06/2014, 22:20

... patients, we hypothesized that there may be another anti -tumor action of AA associated with inhibition of angiogenesis. We subsequently analyzed the effect of high concentrations of ascorbic acid ... metabolism of cells or number of cells. The level of metabolic activity was decreased on 20% for concentra- tions of AA 100–300 mg/dl, but there was no loss of the cells...

Ngày tải lên: 18/06/2014, 15:20

... demonstrating the induction of antigen-specific CTL and the generation of Treg by fusions of DCs and HCC cells. The local tumor- related factors may favor the generation of Treg through the inhibition of ... immunothera- peutic approach to cancer is the immunosuppressive envi- ronment of the growing tumor. A combination of control of Treg and concomitant induct...

Ngày tải lên: 18/06/2014, 15:20

... cells. In line with these data, the extent of the increased expression of these genes was strictly dependent on the number of spiked gp100 280–288 specific CTL. Most importantly, these results indicate ... identification and the sorting of cells endowed with peculiar functional profiles could then be used to address the precise charac- terization of antigen specific T lym...

Ngày tải lên: 18/06/2014, 15:20