báo cáo hóa học:" Aurora kinase inhibitors synergize with paclitaxel to induce apoptosis in ovarian cancer cells" pot
báo cáo hóa học:" Aurora kinase inhibitors synergize with paclitaxel to induce apoptosis in ovarian cancer cells" pot
... mitotic kinase Aurora- A
to be overexpressed in ovarian carcinomas compared to
adenomas. Furthermore, we demonstrated the pan-
Aurora inhibitor VE-465 can synergize with paclitaxel to
induce apoptosis ... purposes)
Journal of Translational Medicine
Open Access
Research
Aurora kinase inhibitors synergize with paclitaxel to induce
apoptosis in ovari...
Báo cáo hóa học: " S110, a novel decitabine dinucleotide, increases fetal hemoglobin levels in baboons (P. anubis)" potx
... methyltransferase (DNMT) inhibitors 5-azacytidine
and 5-aza-2’deoxycyidine (decitabine) have been shown to
increase fetal hemoglobin levels in clinical trials in patients
with sickle cell diseas ... or co-administration of
the cytidine deaminase inhibitor tetrahydouridine (THU;
8, 9). Even though S110 is resistant to cytidine deaminase,
the rapid conversion of S110 into decitabine...
báo cáo hóa học: "Using an electrohydraulic ankle foot orthosis to study modifications in feedforward control during locomotor adaptation to force fields applied in stance" potx
... Adapting to external forces during walking has been proposed as a tool to improve
locomotion after central nervous system injury. However, sensorimotor integration during walking
varies according ... clearly shown in this study that inserting catch
strides during force field exposure provided a valuable
tool to study the feedforward contribution to locomotor
adaptation during stance...
Báo cáo khoa học: "Evaluating language understanding accuracy with respect to objective outcomes in a dialogue system" doc
... Compar-
ing linguistic features for modeling learning in com-
puter tutoring. In Proceedings of the 2007 confer-
ence on Artificial Intelligence in Education: Build-
ing Technology Rich Learning Contexts ... are trying to model.
Thus, the training data for our model consists of
35 instances, each corresponding to a single dia-
logue and the learning gain associated with it. We
can...
Báo cáo sinh học: "A predicted protein, KIAA0247, is a cell cycle modulator in colorectal cancer cells under 5-FU treatment" ppt
... prostate carcinoma
DU145 cells to doxorubicin-induced growth inhibition, G(2)-M arrest,
and apoptosis. Clin. cancer res., 8: 3512-3519, 2002. Clin Cancer Res 2002,
8:3311-3314.
9. Owa T, Yoshino H, ... Cytoplasmic Dynein
Heavy Chain 1 in Patients with Colorectal Cancer. Clin Mol Medicine 2008,
1:6-10.
24. Fingerle-Rowson G, Petrenko O: MIF coordinates the cell cycle with DNA
dam...
Báo cáo sinh học: "Aurora Kinase A expression is associated with lung cancer histological-subtypes and with tumor de-differentiation" doc
... Scagliotti
Abstract
Background: Aurora kinase A (AURKA) is a member of serine/threonine kinase family. Several kinases belonging to
this fami ly are activated in the G2/M phase of the cell cycle being involved in mitotic ... dextran-chain (bio-
tin-free) detection system (EnVision; DakoCytomation),
using 3,3’-diaminobenzidine (DAB; DakoCytomation) as a
chromogen. The sections were...
Tài liệu Báo cáo khoa học: Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase pdf
... analogs with the diacid groups could
occupy the initiator-binding site with enough affinity to
inhibit rubber biosynthesis.
As seen in Fig. 2, chaetomellic acid A (2) was able to
interfere with IPP incorporation ... difference in length of the
inhibitors allows 2 to interact with the polyisoprene
molecules within the rubber particle. In both cases, the
additional interact...
Tài liệu Báo cáo khoa học: Casein kinase 2 specifically binds to and phosphorylates the carboxy termini of ENaC subunits ppt
... one
shown in A). (C) GST fusion proteins containing the C termini of a, b,andcENaC were phosphorylated by fraction 76. Autoradiogram and
Coomassie blue staining are shown.
Fig. 2. Binding of kinases to ... oocytes were injected with a cRNA mixture
containing a, c, and a hemagglutinin A (HA)-tagged
bENaC. The HA epitope was introduced in the ecto
domain at a position shown before not...
Báo cáo Y học: Proteolytic action of duodenase is required to induce DNA synthesis in pulmonary artery fibroblasts A role for phosphoinositide 3-kinase pot
... tdIns 3 -kinase
was immunoprecipitated using antibodies specific to the
p85a regulatory subunit of PtdIns 3 -kinase complexed to
Pansorbin (Calbiochem, Nottingham, UK). PtdIns
3 -kinase activity in immunoprecipitates ... Duodenase-induced DNA syn-
thesis and GTPcS b inding were both f ound to be inhibited
by pertussis toxin, implying a role for G
i/o
. Selective inhi-
bitors of MEK1...
báo cáo hóa học:" Adjuvant therapy of melanoma with interferon: lessons of the past decade" pot
... manifes-
tations of autoimmunity, including autoantibodies to and
clinical manifestations of autoimmunity in melanoma
patients treated with HDI (26% of the total), correlates
with a better RFS and OS. In fact, ... dose-response relation-
ships in this meta-analysis indicated a significant trend
towards increasing RFS benefit with increasing dosage. In
fact, there was evidence...