báo cáo hóa học:" A highly invasive human glioblastoma pre-clinical model for testing therapeutics" pot

... pre-clinically for evaluating potential anti-cancer therapies. We developed an invasive orthotopic human glioblastoma multiforme (GBM) mouse model that enables real-time tumor ultrasound imaging and pre-clinical ... bknudsen@fhcrc.org; Sandra Cottingham - sandra.cottingham@spectrum-health.org; Ping Zhao - ping.zhao@vai.org; Karl Dykema - karl.dykema@vai.org; Brian Cao - brian.cao...

Ngày tải lên: 18/06/2014, 15:20

... moving average method (Vlachos 3 The news articles in one day is treated as a batch. et al., 2004) ,we parameterize p 0 and p 1 with the time index for each batch, formally, we have p 0 (t) and ... frequency state q 1 . Each state has its own emission rate (p 0 and p 1 respectively), and there is a probability for changing state. If an interval of high states appears in the optimal st...

Ngày tải lên: 23/03/2014, 14:20

... English and German data. Most of the top systems boost performance by external hand-crafted resources such as: large gazetteers 4 ; a large amount (2 million words) of labeled data manually annotated ... be adequately learned since we have very large amounts of ‘training data’ for them, which we automatically generate from a very large amount of unlabeled data. The contributions of this...

Ngày tải lên: 23/03/2014, 19:20

... Diagnosis. Hierarchical cluster analysis and TreeView software were used for visualization of the data [14,15]. Gene annotation and functional pathway analysis was based on the Database for Annotation, ... Sunnyvale, CA, USA). Data processing and statistical analyses The raw data set was filtered according to a standard procedure to exclude spots below a minimum intensity that arbitra...

Ngày tải lên: 18/06/2014, 16:20

... interface of human manganese superoxide dismutase. Biochemistry 47, 4621–4628. 18 Vandegriff KD, Malavalli A, Minn C, Jiang E, Lohman J, Young MA, Samaja M & Winslow RM (2006) Oxidation and haem ... superoxide. Chang [2], Alagic [4] and Tarasov [5] have characterized Hb chemically conjugated to SOD alone or SOD combined with catalase, i.e. Hb–SOD and polyHb–SOD–catalase, respectively....

Ngày tải lên: 07/03/2014, 00:20

... proportion- ally limitless. Due to practical, ethical and financial rationalizations, samples are rarely collected with a meth- odology that allows broad testing opportunities and at a time or anatomical ... Standardization, Centralization, Validation Although the principles of standardization and validation of assays are the primary purpose of the working group on "Biomarker Valid...

Ngày tải lên: 18/06/2014, 15:20

... 5'- ATATGGATCCATCTCAGTCCCTCACAAGA-3' (HLA -A) , 5'-TATAGTCGACCACCCGGACTCAGAGTCTCCT-3' and 5'-ATATGGATCCATCTCAGTCCCTCACAAGA-3' (HLA- B), 5'-ACCTGTACGCCAACACAGTG-3' and 5'-GCCAT- GCCAATCTCATCTT-3' ... 5'-GGACGTAGGG- TAAACGTCAGC-3' (TAP2), 5'-CTCGCGCTACTCTCTCTT- 3' and 5'-AAGACCAGTCCTTGCTGA-3' (β2m), 5'-TAT- AGT...

Ngày tải lên: 18/06/2014, 15:20

... Kalka C, Masuda H, Takahashi T, Kalka-Moll WM, Silver M, Kearney M, Li T, Isner JM, Asahara T: Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neo- vascularization. ... CD34, and saline-treated vessels, Characterization of human CD34+ cellsFigure 1 Characterization of human CD34+ cells. A. Scatter analysis reveals a low side scatter and low to interme...

Ngày tải lên: 18/06/2014, 15:20

... 360(9331):427-435. 14. Miyamoto K, Nishigami K, Nagaya N, Akutsu K, Chiku M, Kamei M, Soma T, Miyata S, Higashi M, Tanaka R, Nakatani T, Nonogi H, Take- shita S: Unblinded pilot study of autologous transplantation ... cells from human bone marrow. Proc Natl Acad Sci USA 2000, 97(7):3213-3218. 9. Kawada H, Fujita J, Kinjo K, Matsuzaki Y, Tsuma M, Miyatake H, Mugu- ruma Y, Tsuboi K, Itabashi...

Ngày tải lên: 18/06/2014, 15:20

... now adopted AUC for evaluating predictive ability of classifiers owing to the fact that AUC is a better performance metric than accuracy [31]. In this study, AUC was used as a value to compare the ... as testing data and different nine-tenths of the data as training data. Finally, the average estimate over all runs was reported by running the above regular 10-fold cross-validation fo...

Ngày tải lên: 18/06/2014, 15:20