... features of both HIVinfection and autoimmune diseases. The depletion of the CD4 T lymphocytes is the hallmark of the progression of HIV infection and, in the absence of antiviral treatment, the main ... distinctmonoclonals, two of them preventing, the third one accel-erating the development of the disease [40]. The effect of each reagent on the signaling activated by CD4 via the p56lck interacting ... created upon the interactions of CD4 with gp120, with monoclonal antibodies, or other ligands. The binding of gp120 to CD4 involves a well-defined sitewithin the first Ig-like domain of CD4 (CD4...