... Protein kinase C inhibi- tors. Curr Oncol Rep 4, 37–46. 18 Kheifetsa V & Mochly-Rosen D (2007) Insight into intra- and inter-molecular interactions of PKC: design of specific modulators of kinase ... and to assess their potential anti -in ammatory action. Inhibitory effect of peptides derived from PKI55 on PKC isoforms Results obtained in a previous study of the inhibitio...
Ngày tải lên: 07/03/2014, 05:20
... reminiscent of expansin activity [19]; instead, the observed shrinkage of the walls points towards a predominant role for structural proteins in mediating wall rigidity. Also, expansins cause softening of ... nonreducing conditions, up to 25% reduction in wall extension was still observed when the cysteine proteinase inhibitor N-ethylma- leimide was employed, indicating involvemen...
Ngày tải lên: 08/03/2014, 22:20
Tài liệu Báo cáo khoa học: Upregulation of DR5 by proteasome inhibitors potently sensitizes glioma cells to TRAIL-induced apoptosis doc
... therapies [4]. Interestingly, TRAIL is capable of inducing apoptosis in a wide range of tumor cells, but not in normal tissue. This tumor-selective cytotoxicity has been shown for glioma cells in comparison ... stress-inducible member of the CCAAT ⁄ enhancer-binding protein family, can act as an upstream activator of DR5 in certain types of cancer cells [19,20]. In li...
Ngày tải lên: 18/02/2014, 17:20
Tài liệu Báo cáo khoa học: Proteolysis of Pseudomonas exotoxin A within hepatic endosomes by cathepsins B and D produces fragments displaying in vitro ADP-ribosylating and apoptotic effects doc
... suggesting a high binding capacity of ETA in hepatic parenchyma. Indeed, injection of the toxin into mice has been shown to result in an early and pro- found inhibition of hepatic protein synthesis ... used the in situ rat liver model system following toxin adminis- tration to rats and cell-free hepatic endosomes to relate the endosomal processing of internalized ETA to...
Ngày tải lên: 18/02/2014, 04:20
Tài liệu Báo cáo khoa học: Transcription of individual tRNA1Gly genes from within a multigene family is regulated by transcription factor TFIIIB pdf
... allow TFIIIB binding in an active state (i.e. capable of interacting with TFIIIC to stabilize binding) in the case of tRNA Gly 1 -1 and in an inactive state (incapable of efficient interaction with TFIIIC ... of transcription factors by tRNA Gly 1 -6,7. (A) Binding of TFIIIB alone (in the absence of TFIIIC) to the two genes. (Left) tRNA Gly 1 -1and tRNA Gly 1 -6,7. TFIII...
Ngày tải lên: 20/02/2014, 02:21
Báo cáo khoa học: Interaction of the general transcription factor TnrA with the PII-like protein GlnK and glutamine synthetase in Bacillus subtilis potx
... availability in B. subtilis [1,9]. The feedback-inhibited form of GS binds tightly to TnrA, preventing its binding to DNA, with the most effective feedback inhibitors of GS being glutamine and AMP ... His 6 -NAGK from S. elongatus was injected into FC 1 in a volume of 50 lL at a concentration of 2 nmol ⁄ mL in HBS buffer. This resulted in increases in resonance units...
Ngày tải lên: 06/03/2014, 00:21
Báo cáo khoa học: Discovery of a eugenol oxidase from Rhodococcus sp. strain RHA1 ppt
... similar to that in the native holo-EUGO. SDS ⁄ PAGE analysis of FAD-incubated EUGO resulted in an increase in flavin fluorescence (Fig. 2, lane 3). This shows that the cofac- tor incorporation leads to ... attachment of the FAD cofactor. The successful in vitro cofactor incorporation shows that the covalent incorporation is an autocatalytic pro- cess. Covalent flavinylation is po...
Ngày tải lên: 07/03/2014, 09:20
Báo cáo khoa học: Characterization of a prokaryotic haemerythrin from the methanotrophic bacterium Methylococcus capsulatus (Bath) ppt
... Lillehaug Department of Molecular Biology, University of Bergen, Norway Haemerythrin proteins comprise a family of O 2 -carrry- ing proteins mainly found in a few phyla of marine invertebrates. Members of this ... 2005 FEBS C-terminal end of helix III, pointing towards the inside of the bundle, and Cys128 was located to the random coil of the C-terminal end of the protei...
Ngày tải lên: 07/03/2014, 17:20
Báo cáo Y học: Formation of conjugated D11 D13-double bonds by D12-linoleic acid (1,4)-acyl-lipid-desaturase in pomegranate seeds doc
... cloned into yeast expression vectors under the control of the inducible GAL1 promoter and the encoded proteins were expressed in S. cerevisiae strain INVSc1. In induced cultures of cells harboring ... bond system of the different linolenic acid isomers is determined. Plant oils containing conjugated linolenic acid derivatives are of commercial interest, since they are used as dr...
Ngày tải lên: 08/03/2014, 16:20
Báo cáo khoa học: "Acquisition of Conceptual Data Models from Natural Language Descriptions" doc
... expressed in English. The program made use of the given/new distinction in establishing the co-reference of definite and indefinite descriptions, incrementally constructing extensional semantic interpretations ... practice in two ways: firstly by bringing forward the use of precise formal languages from the coding to the specification phase in the software life-cycle, a...
Ngày tải lên: 09/03/2014, 01:20