... active site region and the S1pocket, whereas the intramolecular connections, forinstance between the TF-binding region and the activesite and between the TF-binding region and the activa-tion ... from the FVIIa molecule that is presentin the active conformation of both the free and TF-bound form, rather than shifting the equilibriumbetween the zymogen-like and active conformations, and ... the vicinity of the S1 pocket [11,34], in the first part of activation loop 3, and in the area of the TF-interactive helix and the 170 loop [8,35], areasthat are stabilized by TF [9,25,26]. The...