... cluster of aromatic residues consisting of Trp344, from one of the four Kv1.2 a-subunits, and Trp345 and Tyr355 of an adjacent a-subunit. The phenol ring of Tyr35 additionally forms an hydrogen bond ... therecognition, interaction and correct positioning of Pi4 on the Kv1.2 channels, and then a tighter interaction takesplace through both hydrophobic forces and hydrogenbonding between Tyr35 (dyad) and ... &Fig. 8. Functional map of Pi4 towards rat Kv1.2 channel, and comparison with that of Pi1. Functional maps of Pi4 [1] and Pi1 [5–7] (A and B,respectively). The structures of scorpion toxins are...