... investigation into the regulation of protein synthesis in mammalian cells, we have investigated the e ffects of inhibition of the p roteasome o n the localiza-tion and integrity of eIF4G in C2C12 ... endothelial cells and i n recovery of cells from wounding [40]. In a variety of cells, in a dditionto the induction of hsp25 and aB-crystallin expression,inhibition of the p roteasome induces ... cleavage[41,48,49]. Rather, inhibition of the proteasome resulted in the induction of hsp25, aB-crystallin and hsp70(Figs 3–5), protecting cells against a poptosis [16,17,20,29–34], and activating signalling...