... list there were eight Clerks of the Roads, viz.:—Two of the Northern Road, two of the Chester Road, two of the Eastern Road, and Two of the Western Road. In 1677, there were, in addition to these ... parcel of ground situate in the Parish of St Werburgh in the City of Bristol on the South West side of and fronting to Small Street aforesaid specified in...
Ngày tải lên: 17/02/2014, 02:20
... for the opposite-base speci city of Fpg and OGG1. Also, although the buffering capacity of KGlu at pH 7.5 is much weaker than that of KP i , the omission of KP i had a rather minor effect on the ... on these sub- strates were at least of the same order of magnitude and the opposite-base speci city (C ⁄ A speci city, defined as the ratio of cleavage of the 8-o...
Ngày tải lên: 18/02/2014, 18:20
Báo cáo khoa học: Combined use of selective inhibitors and fluorogenic substrates to study the specificity of somatic wild-type angiotensin-converting enzyme docx
... ACE species, the catalytic efficiency of the free enzyme corresponds to the sum of the catalytic efficiencies determined for the N-domain and C-domain in the presence of inhib- itor. These results ... to study the spe- ci city of the somatic form of ACE. Thus, with this approach, the catalytic property of each domain towards the hydrolysis of a substrate can b...
Ngày tải lên: 16/03/2014, 13:20
Báo cáo khoa học: "Search in the Lost Sense of “Query”: Question Formulation in Web Search Queries and its Temporal Change" pptx
... largely lost the orig- inal semantics of the word query: they tend to be fragmented phrases (“banana calories”) instead of questions. This could be a result of users learning to express their information ... clustering but on understanding the expression of intent. 3 Method We address the main thesis of the work by retrospec- tively studying queries issued to a search en...
Ngày tải lên: 17/03/2014, 00:20
Báo cáo khoa học: The specificity of alcohol dehydrogenase with cis-retinoids Activity with 11-cis-retinol and localization in retina docx
... physiologically, but their kinetic study gives an estimate of the effect of thecis- bond position on the substrate speci city of human ADH4. The 7-cis-and9-cis-retinol and retinal isomers were the most active ... in the ADH4 M141L mutant. The middle region of the substrate-binding pocket (namely position 141) is therefore essential to define the higher speci city of...
Ngày tải lên: 23/03/2014, 12:20
Tài liệu Bringing Social Impact Bonds to New York City: The City of New York pdf
... guarantee a portion of the investment; • MDRC oversees the day-to-day implementation of the project and manages the Osborne Association and Friends of Island Academy, the two non-profit service providers ... deliver the intervention; • The Vera Institute of Justice, an independent evaluator, determines whether the project achieves the targeted reductions in re...
Ngày tải lên: 15/02/2014, 13:20
Tài liệu FEMA Public Assistance Grant Funds Awarded to the City of Pompano Beach, Florida - Hurricane Wilma docx
... understanding of the City s method of accounting for disaster-related costs and its policies and procedures for administering activities provided for under the FEMA award. RESULTS OF AUDIT The City ... extensions beyond the State's authority appropriate to the situation. It has been 76 months since Hurricane Wilma hit the City of Pompano Beach, Florida....
Ngày tải lên: 17/02/2014, 21:20
Tài liệu Báo cáo khoa học: Molecular and cellular specificity of post-translational aminoacyl isomerization in the crustacean hyperglycaemic hormone family docx
... microscopy study of the neuronal endings in the sinus gland to determine the subcellular localization of the different epimers. Taken together, these results allow a discus- sion of the existence of enzyme(s) ... terminal in the sinus gland, as a result of late and progressive isomerization of the Phe3 of the CHH during the migration of the secretion vesicl...
Ngày tải lên: 18/02/2014, 11:20
Tài liệu Báo cáo khoa học: Substrate specificity of the pseudouridine synthase RluD in Escherichia coli doc
... obtained with the transition at posi- tions 1915 and 1917. These mutations had an effect on the formation of pseudouridine exclusively at the mutant position and did not affect either of the other two ... uridine at other positions in the loop of helix 69 of 23S rRNA variants; (b) substitution of one U by C has no effect on the conversion of others (i.e. formation of...
Ngày tải lên: 18/02/2014, 16:20
Tài liệu Báo cáo khoa học: A knowledge-based potential function predicts the specificity and relative binding energy of RNA-binding proteins ppt
... the final example, a universally con- served component of the core of the signal recognition particle (SRP). The structure of the complex (PDB code: 1HQ1) and the binding affinity of a series of RNA ... tools capable of predicting the speci city of RNA-binding proteins across entire families (such as the RRM superfam- ily), or of redesigning the speci city o...
Ngày tải lên: 18/02/2014, 16:20