... UK;2Department of Chemistry, University of Otago, Dunedin, New Zealand;3Department of Neurology, Medical School, University of Newcastle upon Tyne, UKThe selective manipulation of the expression and ... the vicinity of mtDNA with the resultant binding and selective alkyla-tion leading to a depletion of mtDNA in intact cells(Fig. 1). Here we report the synthesis and characterization of a novel ... mitochondria and cells. Inaddition to facilitating the development of antigenomictherapies, such a reagent might also be useful in investi-gating the rate of turnover of mtDNA and in the derivationof...