... are kept constant on aver- age, with variably large, wave-like deviations. The sudden emergence of a disturbance varia- ble causes larger deviations that quickly nor- malize in a stable control ... 44 45 –67 A U U U U A C G A G A G A A A A A Membrane-bound and export proteins (cf. Plate F.) Genomic DNA Primary RNA (hnRNA) 5’ cap Coding for amino acid no. 5’ end 3’ end 3’-...
Ngày tải lên: 08/04/2014, 12:36
... texture and bulk make ingestion an unpleasant experi- ence. The statins, lovastatin (L), simvasta- tin (S), pravastatin (P), fluvastatin (F), cerivastatin, and atorvastatin, inhibit HMG CoA reductase. ... lipophilic lactone Active uptake of anion HMG-CoA reductase Increased receptor- mediated uptake of LDL Cholesterol Cholesterol Lovastatin Mevalonate3-Hydroxy-3-methyl- glutaryl-CoA HMG-C...
Ngày tải lên: 18/10/2013, 00:15
Color Atlas of Pharmacology (Part 17): Drugs Acting on Motor Systems
... neuron NMDA- receptor Voltage dependent Na + -channel Ca 2 + -channel GABA Inhibitory neuron Glutamate Na + Ca ++ CI – GABA A - receptor NMDA-receptor- antagonist felbamate, valproic acid Enhanced inactivation: carbamazepine valproic ... synaptic cleft by decreasing its re-uptake. Vigabatrin inhibits GABA ca- tabolism. Gabapentin may augment the availability of glutamate as a precur...
Ngày tải lên: 24/10/2013, 19:15
Color Atlas of Pharmacology (Part 18): Drugs for the Suppression of Pain
... subject to terms and conditions of license. Antipyretic Analgesics and Antiinflammatory Drugs 199 A. Antipyretic analgesics Tooth- ache Head- ache Fever Inflammatory pain Pain of colic Acetaminophen ... drugs (NSAIDs). Today, more than 30 sub- stances are available, all of them sharing the organic acid nature of ASA. Structu- rally, they can be grouped into carbonic acids (e.g., dicl...
Ngày tải lên: 24/10/2013, 19:15
Color Atlas of Pharmacology (Part 19): Local Anesthetics
... Naltrex- one may be used as an adjunct in with- drawal therapy. Buprenorphine behaves like a par- tial agonist/antagonist at µ-receptors. Pentazocine is an antagonist at µ-recep- tors and an agonist ... is an opi- um alkaloid (p. 4). Besides morphine, opium contains alkaloids devoid of an- algesic activity, e.g., the spasmolytic pa- paverine, that are also classified as opi- um alkaloids....
Ngày tải lên: 29/10/2013, 02:15
Color Atlas of Pharmacology (Part 20): General Anesthetic Drugs
... glutamatergic transmission via li- gand-gated cation channels of the NMDA subtype, at which ketamine acts as a channel blocker. The non-natural excitatory amino acid N-methyl-D- aspartate is a ... in high-risk patients (e.g., advanced age, liver damage). Neuroleptanesthesia refers to the combined use of a short-acting analge- sic, an injectable anesthetic, a short-act- ing muscle...
Ngày tải lên: 29/10/2013, 02:15
Color Atlas of Pharmacology (Part 21): Psychopharmacologicals
... Biotransformation of benzodiazepines Midazolam Diazepam as glucuronide Active metabolites Inactive Oxazepam Nordazepam Triazolam Brotizolam Oxazepam Lormetazepam Bromazepam Flunitrazepam Lorazepam Camazepam Nitrazepam Clonazepam Diazepam Temazepam Prazepam Applied ... H Benzo diaz epine R 4 N N R 1 R 3 O R 2 Inhibition of excitation Hyper- polari- zation GABA GABA-gated Cl - -channel...
Ngày tải lên: 08/11/2013, 02:15
Color Atlas of Pharmacology (Part 22): Hormones
... hypothy- roidism is treated by oral administra- tion of T 4 . Since too rapid activation of metabolism entails the hazard of car- diac overload (angina pectoris, myocar- dial infarction), therapy ... syn- thesis or the availability of plasmalem- mal glucose transporters via activation of a transcription factor (peroxisome proliferator-activated receptor-"). 262 Hormones Lüllm...
Ngày tải lên: 08/11/2013, 02:15