... 7:556–562. Madeira MD, Sousa N, Lima-Andrade MT, Calheiros F, Cadete-Leite A, Paula-Barbosa MM. Selective vulnerability of the hippocampal pyramidal neurons to hypothyroidism in male and female rats. ... bioconcentrate in the food chain having long half-lives in mammalian fatty tissues. Animals fats and breastfeeding are the most important human dietary sources (Kavlock et al., 1996). Several biomonitoring ... mental retardation, deaf-mutism, impaired voluntary motor activity, and hypertonia (Delange, 2000). In contrast, myxedematous cretinism is characterized by less severe mental retardation and all...