... content of 48.0% [43]. The GC content of the region essential for the biosynthesis of SPA in the otherserotype strains (b–e) of A. actinomycetemcomitans is alsolower than the average GC content of ... characterized the gene clustersresponsible for the biosynthesis of SPAs of A. actinomyce-temcomitans serotypes a, b, c, d, and e [23,29,34–36]. The gene cluster associated with the synthesis of SPA ... GC contents of the genes essential for SPAbiosynthesis in A. actinomycetemcomitans SUNYaB 75are lower than the average GC content (47.8%) of the genes flanking them. The GC contents of ORF2, ORF7,and...