sodium channels and neuronal hyperexcitability

... meeting. 1 Sodium Channels and Neuronal Hyperexcitability. Novartis 241 Copyright & 2002 JohnWiley & Sons Ltd Print ISBN 0-471-48530-6 Online ISBN 0-470-84668-2 SODIUM CHANNELS AND NEURONAL HYPEREXCITABILITY Sodium ... fast inactivation. 2002 Sodium channels and neuronal hyperexcitability. Wiley, Chichester (Novartis Foundation Symposium 241) p 5^20 As w...

Ngày tải lên: 11/04/2014, 10:33

... similarly slow sodium current inactivation and compete for their binding to sodium channels at receptor site-3. Characterization of the binding of 125 I-labelled d-ACTX- Hv1a to various sodium channels ... differentiating between mammalian and insect sodium channels, d-ACTXs differentiate between various insect sodium channels but bind with similar high affinity to rat brain...

Ngày tải lên: 08/03/2014, 16:20

... receptor site-4 in insect sodium channels [19,21], was used in competition binding assays of LqhIT2 and Lqhb1 toxins to cockroach neuronal membranes. Sodium channel expression and two-electrode voltage-clamp ... affecting sodium channels. J. Toxicol. Toxin Rev. 17, 131–159. 3. Gordon, D. (1997) Sodium channels as targets for neurotoxins: mode of action and interaction of...

Ngày tải lên: 31/03/2014, 01:20

... promoter in human immune cells and neuronal cells by leptin and progesterone Mauro Maccarrone 1,2 , Valeria Gasperi 3 , Filomena Fezza 1 , Alessandro Finazzi-Agro ` 3 and Antonello Rossi 3 1 Department ... 1 and Fig. 4). Fig. 4. Analysis of FAAH promoter by transient expression. (A) Proximal upstream r egion of human FAAH gene. Left and right handed arrows denote SP1 sites in the...

Ngày tải lên: 30/03/2014, 15:20

Ngày tải lên: 07/05/2014, 13:31

... between conformal channels and drilled cooling channels has also beenconductedby Sachsetal.[3]. Theybased their investiga- tion on modelling the core and cavity coupled with software using both techniques and ... four channels was created followingthe surfaceofthe object, withthreechannelsplaced to cool the lateral surface and one to cool the bottom one. 5.4. Core channels pos...

Ngày tải lên: 12/02/2014, 22:20

... Cu(I) 4 ,Cu(I) 4 MT3 and Cu(I) 6 ,Cu(I) 6 MT3]. The determination of a 3D struc- ture seems crucial for understanding the differences between Cu–MT3 and Cu–MT1 ⁄ 2 (structure also not known) and the presence and ... region and a Thr in position 5. Moreover, a conserved Cys-Pro-Cys-Pro motif between positions 6 and 9 is unique to MT3 [1,4,5]. All mammalian MTs can bind a variety of...

Ngày tải lên: 16/02/2014, 15:20

... differences between GIF and MT1 and MT2 include a Cys-Pro-Cys-Pro(6–9) motif and Thr5 in the b-domain of GIF and a different amino acid structure in the a-domain [32]. Structural and cell biology studies ... synthesis of GIF is highly localized to specific subsets of cortical and hippocampal neurons, and is found within the axons and dendrites. Neuronal pro- duction of GIF is...

Ngày tải lên: 16/02/2014, 15:20

... containing ethidium bromide, and bands were revealed under UV. For pri- miR9-1, pri-miR9-2 and pri-miR9-3, first-strand cDNA synthesis was carried out using random-hexamer primer and promoter primers ... 10 5 cells to determine the expressions of miR9 and miR9*. Luciferase assays for FLuc and GLuc activities P19 and HeLa cells were washed with NaCl ⁄ P i and treated with lysis bu...

Ngày tải lên: 18/02/2014, 17:20