glutamate and addiction

glutamate and addiction

... on glutamate and alcohol, who include Peoples; Crew, Rudolph, and Chandler; Becker and Redmond; Krystal, Petrakis, D’Souza, Mason, and Trevisan; Zieglgänsberger, Rammes, Spanagel, Danysz, and ... of glutamatergic systems in addiction disorders is now off to a solid beginning. With the recent advance and approval of glutamatergic antago- nists for the indication of alcohol abus...

Ngày tải lên : 11/04/2014, 09:43

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Báo cáo khoa học: Crystal structure of salt-tolerant glutaminase from Micrococcus luteus K-3 in the presence and absence of its product L-glutamate and its activator Tris pdf

... and TG (T ⁄ TG), N and G (N ⁄ G), G and TG (G ⁄ TG), and N and T (N ⁄ T) structures are superim- posed. Effects of (A) L -glutamate (T ⁄ TG and N ⁄ G) and (B) Tris (G ⁄ TG and N ⁄ T) on the structure ... T); in the presence of l -glutamate (referred to as G); and in the presence of both Tris and l -glutamate (referred to as TG). Furthermore, the li- ganded (TG) and un...

Ngày tải lên : 06/03/2014, 09:22

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Treatment Planning for Person-Centered Care: The Road to Mental Health and Addiction Recovery docx

... assumptions, and values. Words communicate ideas that go beyond the terms and phrases themselves. But this is by no means static; there are trends and periodic shifts that impact how we think and understand ... rehabilitation, and so forth. Recognizing that there are different models, different philosophies and attitudes, and a range of professional disciplines and clinical tr...

Ngày tải lên : 29/03/2014, 00:21

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Tài liệu Báo cáo khoa học: Implication of the glutamine synthetase ⁄glutamate synthase pathway in conditioning the amino acid metabolism in bundle sheath and mesophyll cells of maize leaves doc

... little contamination from xylem, and vice versa. Glx (glutamine and glutamate: ﬁve carbon amide and amino acid) and Asx (asparagine and aspartate: four carbon amide and amino acid) were found to ... GS1 and chlo- roplast GS2) and glutamate synthases (ferredoxin-GOGAT and NADH- GOGAT) in the inorganic nitrogen assimilation and reassimilation into amino acids between bund...

Ngày tải lên : 18/02/2014, 18:20

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Tài liệu Báo cáo khoa học: Functional studies of active-site mutants from Drosophila melanogaster deoxyribonucleoside kinase Investigations of the putative catalytic glutamate–arginine pair and of residues responsible for substrate speciﬁcity docx

... purines and negative cooperativity towards dThd and dCyd was observed. The Q81N mutation showed a 200- and 100-fold increase in K m , whereas k cat was decreased ﬁve- and twofold for dThd and dCyd, ... H and Q, residue Y70 to W, residue Q81 to N and residue R105 to K and H. The kinetic properties of the active site mutants are summarized in Table 1. All mutants were characteri...

Ngày tải lên : 19/02/2014, 02:20

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Tài liệu Báo cáo khoa học: Puriﬁcation and characterization of glutamate N-acetyltransferase involved in citrulline accumulation in wild watermelon doc

... characterized wild watermelon glutamate N-acetyltransferase (CLGAT) that catalyses the trans- acetylation reaction between acetylornithine and glutamate to form acetylglutamate and ornithine, thereby ... enzyme is glutamate N-acetyltransferase (GAT, EC 2.3.1.35), which catalyses transfer of the acetyl group from N-acetylornithine into glutamate yielding ornithine and N-acetylg...

Ngày tải lên : 20/02/2014, 03:20

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Báo cáo khoa họcRe-engineering the discrimination between the oxidized coenzymes NAD+ and NADP+ in clostridial glutamate dehydrogenase and a thorough reappraisal of the coenzyme speciﬁcity of the wild-type enzyme docx

... oxidized coenzymes NAD + and NADP + in clostridial glutamate dehydrogenase and a thorough reappraisal of the coenzyme specificity of the wild-type enzyme Marina Capone*, David Scanlon, Joanna Griffin and Paul ... in higher animals and in Archaea), and NADP + -specific members, respectively. Most of these are evolutionarily and structurally related, in many cases quite closely, des...

Ngày tải lên : 06/03/2014, 00:20

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Báo cáo khoa học: Interactions between coenzyme B12 analogs and adenosylcobalamin-dependent glutamate mutase from Clostridium tetanomorphum pot

... 50, 75 and 120 lm cofactor, and the K m and k cat for AdoCbi-GDP were determined in the presence of 20, 70, 100, 150 and 200 lm cofactor. The reaction was initiated by adding l -glutamate and incubating ... the MeCbi -glutamate mutase, AdoCbi -glutamate mutase and AdoCbi-GDP -glutamate mutase complexes were measured. A red shift was observed in the spectra of protein-bound MeC...

Ngày tải lên : 07/03/2014, 04:20

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Báo cáo khoa học: Amino acids at the N- and C-termini of human glutamate carboxypeptidase II are required for enzymatic activity and proper folding pptx

... both in cell lysates and conditioned media, and the results are summarized in Fig. 2 and Table 2, respectively. Of the 13 variants, only 274/587 (the putative catalytic domain) and 274/750 (the polypeptide ... electroblotted onto a nitro- cellulose membrane, and immunostained as described in the Materials and methods. Relative band intensities were recorded using a CCD camera, an...

Ngày tải lên : 07/03/2014, 15:20

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