glutamate and addiction

... on glutamate and alcohol, who include Peoples; Crew, Rudolph, and Chandler; Becker and Redmond; Krystal, Petrakis, D’Souza, Mason, and Trevisan; Zieglgänsberger, Rammes, Spanagel, Danysz, and ... of glutamatergic systems in addiction disorders is now off to a solid beginning. With the recent advance and approval of glutamatergic antago- nists for the indication of alcohol abus...

Ngày tải lên: 11/04/2014, 09:43

... and TG (T ⁄ TG), N and G (N ⁄ G), G and TG (G ⁄ TG), and N and T (N ⁄ T) structures are superim- posed. Effects of (A) L -glutamate (T ⁄ TG and N ⁄ G) and (B) Tris (G ⁄ TG and N ⁄ T) on the structure ... T); in the presence of l -glutamate (referred to as G); and in the presence of both Tris and l -glutamate (referred to as TG). Furthermore, the li- ganded (TG) and un...

Ngày tải lên: 06/03/2014, 09:22

... assumptions, and values. Words communicate ideas that go beyond the terms and phrases themselves. But this is by no means static; there are trends and periodic shifts that impact how we think and understand ... rehabilitation, and so forth. Recognizing that there are different models, different philosophies and attitudes, and a range of professional disciplines and clinical tr...

Ngày tải lên: 29/03/2014, 00:21

... little contamination from xylem, and vice versa. Glx (glutamine and glutamate: five carbon amide and amino acid) and Asx (asparagine and aspartate: four carbon amide and amino acid) were found to ... GS1 and chlo- roplast GS2) and glutamate synthases (ferredoxin-GOGAT and NADH- GOGAT) in the inorganic nitrogen assimilation and reassimilation into amino acids between bund...

Ngày tải lên: 18/02/2014, 18:20

... purines and negative cooperativity towards dThd and dCyd was observed. The Q81N mutation showed a 200- and 100-fold increase in K m , whereas k cat was decreased five- and twofold for dThd and dCyd, ... H and Q, residue Y70 to W, residue Q81 to N and residue R105 to K and H. The kinetic properties of the active site mutants are summarized in Table 1. All mutants were characteri...

Ngày tải lên: 19/02/2014, 02:20

... characterized wild water- melon glutamate N-acetyltransferase (CLGAT) that catalyses the trans- acetylation reaction between acetylornithine and glutamate to form acetylglutamate and ornithine, thereby ... enzyme is glutamate N-acetyltransferase (GAT, EC 2.3.1.35), which catalyses transfer of the acetyl group from N-acetylornithine into glutamate yielding ornithine and N-acetylg...

Ngày tải lên: 20/02/2014, 03:20

... oxidized coenzymes NAD + and NADP + in clostridial glutamate dehydrogenase and a thorough reappraisal of the coenzyme specificity of the wild-type enzyme Marina Capone*, David Scanlon, Joanna Griffin and Paul ... in higher animals and in Archaea), and NADP + -specific members, respectively. Most of these are evolutionarily and structurally related, in many cases quite closely, des...

Ngày tải lên: 06/03/2014, 00:20

... 50, 75 and 120 lm cofactor, and the K m and k cat for AdoCbi-GDP were determined in the presence of 20, 70, 100, 150 and 200 lm cofactor. The reaction was initiated by adding l -glutamate and incubating ... the MeCbi -glutamate mutase, AdoCbi -glutamate mutase and AdoCbi-GDP -glutamate mutase complexes were measured. A red shift was observed in the spectra of protein-bound MeC...

Ngày tải lên: 07/03/2014, 04:20

... both in cell lysates and conditioned media, and the results are summarized in Fig. 2 and Table 2, respectively. Of the 13 variants, only 274/587 (the putative catalytic domain) and 274/750 (the polypeptide ... electroblotted onto a nitro- cellulose membrane, and immunostained as described in the Materials and methods. Relative band intensities were recorded using a CCD camera, an...

Ngày tải lên: 07/03/2014, 15:20