gene regulation and metabolism

... questions of gene reg- ulation and metabolism without explicit mention of the connection between networks and the phenotype. One of the challenges, compu- tationally, in understanding gene regulation ... postgenomic computational research. In 1995 and 1998 we participated in the organization of two Dagstuhl seminars centered on modeling and ix Preface simulation of metabolism...

Ngày tải lên: 08/04/2014, 12:45

... questions of gene reg- ulation and metabolism without explicit mention of the connection between networks and the phenotype. One of the challenges, compu- tationally, in understanding gene regulation ... postgenomic computational research. In 1995 and 1998 we participated in the organization of two Dagstuhl seminars centered on modeling and ix Preface simulation of metabolism...

Ngày tải lên: 11/04/2014, 00:45

... proliferation and metastasis (Hanahan and Weinberg 2000). Genes modified in cancer are classified as oncogenes and tumor sup- pressor genes that have been activated by gain-of-function mutations and inactivated ... suppressor gene, the retinoblas- toma gene (Rb) has been extensively studied. Numerous biochemical and genetic studies have elucidated in great detail the function of th...

Ngày tải lên: 25/10/2013, 21:20

... RhoA GTPase and p38 in transcriptional and post-transcriptional regulation of the CTGF/CCN2 gene In order t o determine whether CTGF/CCN2 expression occurs via increased transcription and/ or by ... transcripts and t he role of RhoA GTPase and p38 signaling in such a regulation, nuclear run-on assays and message stability analyses were carried out. The transcription rate of th...

Ngày tải lên: 19/02/2014, 16:20

... two-hybrid EcR gene switch with high ligand sensitivity and low background expression levels when compared to the earlier versions of EcR gene switches [14]. The chemical-inducible gene regulation ... LmRXR and HsRXR LBDs as a partner of CfEcR, we were able to combine these two impor- tant aspects of the gene switch together and develop a tight EcR gene regulation system w...

Ngày tải lên: 16/03/2014, 06:20

... involved. Discussion From its identification as a Drosophila gene responsible for resistance to morphogenetic and toxic effects of JH and JHAs, the Met gene product has been implicated to have an involvement ... activator of gene regulation [45]. Contrary to this, MET exists in the nucleus even in the absence of ligand. Upon ligand binding, it becomes a transcriptional activator. T...

Ngày tải lên: 16/03/2014, 18:20

... tight and subtle homeostatic control, involving gene- expression and metabolic regulation of both topoisomerase I and DNA gyrase Jacky L. Snoep 1,2 , Coen C. van der Weijden 1 , Heidi W. Andersen 2,3 , ... sensitive, and that the pA1lacO-1 promoter and the lacI q1 gene are surrounded by a DNA fragment originating from upstream the gyrA gene and a fragment containing the N-t...

Ngày tải lên: 18/03/2014, 01:20

... including positive-strand and minus-strand DNA synthesis, pre-genomic RNA pack- aging, and virion formation and release [17,18]. This core protein is a phosphoprotein, and its function may be ... proteins is important for assembly and function of the spliceosome and for proper regulation of alternative splicing, and also controls their subnuclear localization and nucleocytop...

Ngày tải lên: 23/03/2014, 06:20

... & Varmus, H.E. (2001) Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes Dev. 15, 3249–3262. 147. ... of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators. Genes Dev. 12, 2852–2862. 99. Pannell, D. & Ellis, J. (2001) Sil...

Ngày tải lên: 23/03/2014, 21:20

... ribosome assembly, sulfur metabolism and RNA metabolism occur in the oxidative phase; cell division and mitochondrial biogenesis occur in the first reductive phase and glycolysis and fatty acid oxidation occur ... Extensive and diver- gent circadian gene expression in liver and heart. Nature 417, 78–83. 16 Rudic RD, McNamara P, Curtis AM, Boston RC, Panda S, Hogenesch JB &...

Ngày tải lên: 30/03/2014, 04:20