absorption and drug development
absorption and drug development
... chemistry space, and especially that clinically useful drugs appear to exist as small tight clusters in chemistry space: Absorption and Drug Development: Solubility, Permeability, and Charge State. ... dose of the drug, unless the dose exceeds the solubility limit at the pH considered, in PERMEABILITY-SOLUBILITY-CHARGE STATE 9 ABSORPTION AND DRUG DEVELOPMENT Solubility, Pe...
Ngày tải lên: 10/04/2014, 10:58
Tài liệu Lipases and Phospholipases in Drug Development pptx
... suggesting that Asp 126 and Asp 156 are involved in sub- strate recognition, and that Asp 295, His 151 and His 296 are essential for the hydrolytic activity [89]. Note that His 136 and His 272 are essential ... for the ac- tivity of nSMase 1 [60, 62]. His 134 and His 252 of DNase correspond to histi- dines 136 and 272 of nSMase1, and to histidines 151 and 296 of B. cereus SMas...
Ngày tải lên: 17/02/2014, 05:20
Báo cáo khoa học: B1–Proteases as Molecular Targets of Drug Development B1-001 DPP-IV structure and inhibitor design ppt
... proteasome and confers ameliorated response to oxidative stress and higher survival rates N. Chondrogianni and E. S. Gonos Molecular and Cellular Ageing Laboratory, Institute of Biological Research and ... and diagnostic impact of cathepsins B, L and H from human tissues extracts (normal and tumor tissue) and extracellular fluids (such as plasma and urine) and a1-proteina...
Ngày tải lên: 23/03/2014, 15:20
Báo cáo y học: "A prospective observational study of the relationship of critical illness associated hyperglycaemia in medical ICU patients and subsequent development of type 2 diabetes"
... sepsis and septic shock); ii) acute coronary syndrome (myocardial infarction and unstable angina); and iii) all other admis- sion diagnoses. This division was made due to the fact that sepsis and ... contributions IG conceived and organized the study, participated in patients' inclusion and follow-up, performed statistical analyses, analyzed results and wrote the manu- scri...
Ngày tải lên: 25/10/2012, 10:02
Báo cáo y học: "Advances in Molecular Diagnosis of HBV Infection and Drug Resistance"
... United States, and Central Africa; B and C predominate in Asia; D is associated with southern Europe, the Middle East, and India; E is uniquely African; and F is found in Central and South America ... well standardized Can indicate and confirm emergence of antiviral resistance Wide variation in test sensitivities Direct marker and gold standard for HBV viral replication No g...
Ngày tải lên: 03/11/2012, 09:41
Marketing mix solutions to develop Agribank cards at Vietnam Bank for Agriculture and Rural Development – Thanh Xuan branch
... ACTIVITIES TO BANKCARD AND ACTUAL STATE OF AGRIBANK CARDS 2.1. Introduction of Vietnam Bank for Agriculture and Rural Development (Agribank) - Thanh Xuan branch 2.1.1. Foundation and development of ... TO BANKCARD AND ACTUAL STATE OF AGRIBANK CARDS 9 2.1. Introduction of Vietnam Bank for Agriculture and Rural Development (Agribank) - Thanh Xuan branch 9 2.1.1. Foundation...
Ngày tải lên: 09/11/2012, 15:31