... abnormallyhigh brain levels of PA have been reported in a mur-ine model of cerebral malaria, a frequently fatal com-plication of Plasmodium falciparum infection; in the same model, pharmacological reduction ... glycolysis.AbbreviationsACMS, a- amino-b-carboxymuconate-e-semialdehyde; ACMSD, a- amino-b-carboxymuconate-e-semialdehyde decarboxylase; DHAP,1,3-dihydroxyacetonephosphate; PA, picolinic acid; QA, quinolinic ... with the non-enzymatic synthesis of QA, ACMSD ultimatelycontrols the metabolic fate of tryptophan catabolismalong the kynurenine pathway, and is a medically rele-vant enzyme in light of the...