... β1.A number of proteinase families are capable of generating the proteolytic fragments of versi‐can. Matrix metalloproteinase (MMP )-1 , -2 , -3 , -7 , and -9 , ADAMTS-1, -4 , -5 and -9 cleaveversican ... malignan‐Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications10cies. Elevated versican production occurs in either the tumor cells or the stromal cellssurrounding the tumor. ... genetic instability of high gradegliomas provides the way of angiogenesis independently of hypoxia (such as chronic HIFEvolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications14activation...