Báo cáo khoa học: "Fifth Conference of the European Chapter of the Association for Computational Linguistics" potx

... The preparation of the Fifth Conference of the European Chapter of the Association for Computational Linguistics was done, without doubt, under extraordinary circumstances. To characterize the ... ...

Tài liệu Báo cáo khoa học: "Sixth Conference of the European Chapter of the Association for Computational Linguistics" potx

... alt="" Sixth Conference of the European Chapter of the Association for Computational Linguistics Proceedings of the Conference 21 - 23 April 1993 9~~ OTS - Research Institute for Language ... This volume contains the papers prepared for the Sixth Conference of the European Chapter of the Association for Computational Linguistics, held 19-23 April 1993 in Utrecht. The Programme Committee ... Preface This year for the first time the European Conference of the ACL includes a student session. This part of the conference was organized by the Dutch Student Association for Computa- tional...

Báo cáo khoa học: " Medication errors: a prospective cohort study of hand-written and computerised physician order entry in the intensive care unit"

... (where the patient received the drug). The intercepted errors were scored separately on the basis of their possible impact on the patient, if the prescriptionhad been administered as prescribed. The ... blindedto the prescribing system; this could have introduced the potential for bias in the results and is a limitation of the study.Medical errors are among the leading causes of death in the United ... recorded details of MEs and the totalnumber of drugs prescribed daily during the data collectionperiods, during the course of his normal chart review.Results The total proportion of MEs was significantly...

Tài liệu Báo cáo khoa học: Erythrochelin – a hydroxamate-type siderophore predicted from the genome of Saccharopolyspora erythraea docx

... assembly of for- oxymithine by a synthetase lacking all E-domains. The lack of sequence information for the S. nitrosporeusgenome impeded the identiﬁcation of a biosyntheticmachinery governing foroxymithine ... to the identiﬁcation of the second siderophore(data not shown). We therefore assume that either the extraction conditions were inadequate for the iso-lation of the natural product, or that the ... characterization of these compounds isgrowing and may result in the synthesis of speciﬁcinhibitors based on the structure of the pathogensiderophore [16].A promising approach for the isolation of secondarymetabolites,...

Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx

... synthesis of pantothe-nate from low amounts of pantoate [9]. Here, wereport the results of the structural studies of the panto-ate-bound form of the N-terminal domain of E. coliPS (nPS). The ... occupy allowed regions of the Rama-chandran map [32,33]. Comparison of the monomer of the substrate-free form of E. coli PS [13] with the monomers of nPS in the pantoate-bound form at fulloccupancy ... of pantoate. The electron density for the two molecules of pantoate bound at the active site of nPS can be unambiguously distinguished in Fig. 4B. The crystal structures of the protein were of...

Tài liệu Báo cáo khoa học: Top-down MS, a powerful complement to the high capabilities of proteolysis proteomics pdf

... to, for example, a single substitution;MS ⁄ MS will then show the substituent positions of dif-ferent isomers. A problem for MS ⁄ MS of either the peptides for the bottom-up approach or of the ... a molecular mass of 16 309.7 Da, butthis matched none of the DNA-predicted proteins.MS ⁄ MS of these ions gave the C-terminal sequence of Fig. 5. These and all other peaks of that spectrum ... inhibitors. Tocheck for covalent modiﬁcations of the enzyme, the effect of the inhibitor on the molecular mass value of HAD was measured; instead of an adduct increase, orno change, the value had...

Tài liệu Báo cáo khoa học: Oxidized elaﬁn and trappin poorly inhibit the elastolytic activity of neutrophil elastase and proteinase 3 pdf

... respectively. On the other hand, oxidation of M25L elaﬁn and M63L trappin did not signiﬁcantlyaffect their Ki for NE (Table 2). We therefore concludethat the oxidant-promoted alteration of the Ki of elaﬁnand ... binding of the methioninesulfoxide residue at the S1¢ subsite of the active centers of NE and Pr3. The fact that the S1¢ subsite of Pr3 issigniﬁcantly smaller than that of NE [21] might thenexplain ... cathepsin G [3]). The two former proteins aremainly synthesized in the liver and reach the lung via the blood circulation. They are irreversible inhibitorsthat belong to the serpin family. Their...

Tài liệu Báo cáo khoa học: Diversity and junction residues as hotspots of binding energy in an antibody neutralizing the dengue virus doc

... stronglydecreased the rate of association, possibly by perturbing the topology of the electrostatic ﬁeld of the antibody. These data will help to improve the properties of mAb4E11 for therapeutic applications ... the degrees of freedom for the motion of the antigen that are lostupon immobilization, are identical for the wild-typeand mutant Fabs [20,35]. We found that the values of DDG and DDG¢ for the ... adopts an exten-ded conformation in > 90% of the cases [33]. There-fore, mutation L-P95A of Fab4E11 could modify the structure of L-CDR3 both by changing the conforma-tion of residue L-95 from...

Tài liệu Báo cáo khóa học: Trichostatin A reduces hormone-induced transcription of the MMTV promoter and has pleiotropic effects on its chromatin structure pptx

... and the cleavage of DNA by alkali [31]. The method allows easy detection of DNA–protein interactions via the N7 position of guaninesin the major groove and via the N3 position of adenines in the ... the structure of chromatin incorpor-ating them. To see whether the increased transcriptionleakage observed at early addition of TSA can be explainedby an accumulation of acetylated forms of ... coupled with the topologychanges resulting from the loss of 1.5 superhelical turns of the DNA over the whole construct, suggest that the chromatin is indeed more relaxed in the absence of hormone....

Tài liệu Báo cáo khoa học: A novel coupled enzyme assay reveals an enzyme responsible for the deamination of a chemically unstable intermediate in the metabolic pathway of 4-amino-3-hydroxybenzoic acid inBordetellasp. strain 10d doc

... the determination of released ammonia. The coupled enzymeassay revealed the mechanism of the deamination reactionand the subsequent metabolism, including the deaminationstep. The product formed ... to clarify the stoichiometry by adding a small amount of the puriﬁeddioxygenase to the reaction mixture with a large excess of the puriﬁed enzyme reported here to avoid the formation of 2,5-pyridinedicarboxylic ... 2004present in cell extracts of succinate/glucose-grown cells;therefore, the s ynthesis of the e nzyme was indu cible. Table 1shows a summary of a typical enzyme puriﬁcation. The enzyme was puriﬁed...

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