Báo cáo Y học: NMR structure of the HIV-1 regulatory protein Vpr in H2O/trifluoroethanol Comparison with the Vpr N-terminal (1–51) and C-terminal (52–96) domains pot

Báo cáo Y học: NMR structure of the HIV-1 regulatory protein Vpr in H2O/trifluoroethanol Comparison with the Vpr N-terminal (1–51) and C-terminal (52–96) domains pot

Báo cáo Y học: NMR structure of the HIV-1 regulatory protein Vpr in H2O/trifluoroethanol Comparison with the Vpr N-terminal (1–51) and C-terminal (52–96) domains pot

... modifications when comparing the isolated domains of (1–51 )Vpr [25] and (52–96 )Vpr [26] with the intact Vpr protein. The differences in structure are localized to the N-terminal domain. The secondary structures ... portion of the protein and allow its tight binding to Lys-tRNA synthetase [15]. The C-terminal domain (52–96 )Vpr and not the N-term...
Ngày tải lên : 31/03/2014, 23:20
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Tài liệu Báo cáo khoa học: NMR structure of AII in solution compared with the X-ray structure of AII bound to the mAb Fab131 pptx

Tài liệu Báo cáo khoa học: NMR structure of AII in solution compared with the X-ray structure of AII bound to the mAb Fab131 pptx

... pointing in opposite directions. The stabilization of the folded conformation can be explained by the stacking of the Val3 side chain with the Pro7 ring and by a hydrophobic cluster formed by the ... purifying and handling integral membrane proteins. The instability of these proteins in environments lacking phospholipids and the tendency for them to aggregate...
Ngày tải lên : 20/02/2014, 23:20
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Tài liệu Báo cáo Y học: Solution structure of the mEGF/TGFa44250 chimeric growth factor doc

Tài liệu Báo cáo Y học: Solution structure of the mEGF/TGFa44250 chimeric growth factor doc

... by modification of the standard cysteine residue in the DYANA library [53]. A pseudoatom was included instead of the HG atom and a bridge was formed by superimposition of the pseudoatoms on the ... reduced mobility with respect to the rest of the structure. Further studies of the receptor bound forms of the chimera and other related ligands will be necess...
Ngày tải lên : 22/02/2014, 07:20
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Báo cáo Y học: Solution structure of the Alzheimer amyloid b-peptide (1–42) in an apolar microenvironment Similarity with a virus fusion domain potx

Báo cáo Y học: Solution structure of the Alzheimer amyloid b-peptide (1–42) in an apolar microenvironment Similarity with a virus fusion domain potx

... surprising similarity of this structure, as well as the sequence of the C-terminal moiety, with those of the fusion domain of in uenza hemagglutinin suggests a direct mechanism of neurotoxicity. Keywords: ... been proposed for this structure [37]. TheoverallshapeofAb-(1–42) is strongly reminiscent of the structure of the fusion domain of in uenza hemagglu-...
Ngày tải lên : 08/03/2014, 09:20
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Báo cáo Y học: Solution structure of the HIV gp120 C5 Domain pptx

Báo cáo Y học: Solution structure of the HIV gp120 C5 Domain pptx

... remaining domains of gp120 in the native structure. The carboxy terminal end of the C5 domain would be attached to the amino terminus of gp41 in the unprocessed form (termed gp160). Note that the last ... splittingÕ in the TOCSY spectra of C5 indicates that the trans isomer is the major isomer. Interestingly, the H N and H a line-widths of the region...
Ngày tải lên : 08/03/2014, 16:20
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Báo cáo Y học: Crystal structure of the catalytic domain of a human thioredoxin-like protein pdf

Báo cáo Y học: Crystal structure of the catalytic domain of a human thioredoxin-like protein pdf

... 1ERT (crystal structure of oxidized and reduced human thioredoxin, 1–105), 1DBY (NMR structure of thioredoxin in Chlamydomonas reinhardtii, 1–107), 1MEK (NMR structure of thioredoxin domain of protein- disulfide ... forms and dissimilar intermolecular contacts near the active site in the crystal, the conformation of the active site (-Cys-Gly-Pro- Cys-) of...
Ngày tải lên : 08/03/2014, 22:20
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Báo cáo khoa học: NMR structure of the thromboxane A2 receptor ligand recognition pocket pot

Báo cáo khoa học: NMR structure of the thromboxane A2 receptor ligand recognition pocket pot

... extracellular domain. The second step will then be the deposition of the ligand into the TM pocket causing the conformation change of the receptor and triggering the coupling of the receptor with the G protein ... protein in the intracellular domain s. The first step of binding determines the ligand selectively and the second step of binding is r...
Ngày tải lên : 16/03/2014, 18:20
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Báo cáo Y học: Solution structure of a hydrophobic analogue of the winter flounder antifreeze protein doc

Báo cáo Y học: Solution structure of a hydrophobic analogue of the winter flounder antifreeze protein doc

... study, which can be performed in solution, seems particularly interesting in view of the fact that the interaction of water with the putative ice-binding surface of TTTT in the single crystal ... interactions, has been reported very recently [24]. This study has allowed a comparison of the hydrogen bonding between the protein in water and the protein i...
Ngày tải lên : 31/03/2014, 21:21
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Tài liệu Báo cáo Y học: Functional analysis of DM64, an antimyotoxic protein with immunoglobulin-like structure from Didelphis marsupialis serum pdf

Tài liệu Báo cáo Y học: Functional analysis of DM64, an antimyotoxic protein with immunoglobulin-like structure from Didelphis marsupialis serum pdf

... contains five Ig-like domains. A comparison of the first three domains of DM64 and a 1 B- glycoprotein shows that they are homologous to the three DM43 domains [24]. Each of these domains in the ... a 1 B-glycoprotein, indicating the presence of five immunoglobulin-like domains. DM64 neutralized both the in vivo myotoxicity and the in vitro cytotoxicity...
Ngày tải lên : 21/02/2014, 01:21
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Báo cáo Y học: Functional expression of human liver cytosolic b-glucosidase in Pichia pastoris Insights into its role in the metabolism of dietary glucosides ppt

Báo cáo Y học: Functional expression of human liver cytosolic b-glucosidase in Pichia pastoris Insights into its role in the metabolism of dietary glucosides ppt

... liver. Furthermore, we investigated the speci®city of the human CBG with r espect to the glycone and aglycone moieties, and in particular characterized the ef®ciency of the enzyme in hydrolysing a ... (4NPGlc), incubating for 30 min at 37 °C, and measuring the rel ease of 4NP. Protein assays and protein sequencing Total protein in crude and semipuri®e...
Ngày tải lên : 08/03/2014, 16:20
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