... and
ultimately abolished, the increase in c-myc gene expression
elicited by PMA in serum-free cells. These results suggest
that inhibition of MEK/ERK signaling by NAMI-A may
have an important role in modulating ... be
lying upstream of ERK1/2.
Recent observations indicate that activation of Raf by
PMA may trigger the same signaling pathway as oncogenic
Raf, or Raf activati...
... hardly inhibited by MU
up to 1.0 m
M
(data not shown). This result suggest that the
inhibition of HA production was not caused by direct
inhibition of HAS activity.
Effect of MU on HAS activity in ... HA released
into the culture medium was measured by the sandwich
binding protein assay using hyaluronan binding protein
(HABP) according to the manufacture’s instructions for t...
... mgÆmL
)1
providing complete inhibition of apoC-II
amyloid formation, equivalent to a 30 : 1 molar excess of
apoC-II to clusterin (Fig. 1B). The specificity of the
inhibition of amyloid formation by clusterin ... levels of
clusterin, derived from either plasma or semen, potently
inhibit amyloid formation by apoC-II. Inhibition is
dependent on apoC-II concentration, with more...
... Inhibition of glycosyl-phosphatidylinositol biosynthesis in
Plasmodium
falciparum
by C-2 substituted mannose analogues
Cristiana Santos de Macedo, Peter ... study glycosylphosphatidylinositol (GPtdIns)
biosynthesis and GPtdIns protein anchoring in protozoal
and mammalian systems. The effects of these analogues on
GPtdIns biosynthesis and GPtdIns-protein ... t...
... was
reduced by 60% in the presence of 500 l
M
Cl-tetracycline
and by 95% in t he presence of 500 l
M
erythromycin and
streptomycin (Fig. 2B,C). Tetracycline at 500 l
M
inhibited
splicing by only 1 0% ... splicing inhibition by
tetracycline is n egligible (Fig. 2). The sixfold stron ger
splicing inhibition by Cl-tetracycline may be explained by
the a dditional s ize and...
... processes including: activation of
apoptosis in Jurkat T-cells [5], inhibition of platelet
aggregation [6,7] and inhibition of in ammatory cytokine
production in macrophages [8]. Curcumin has also ... activity of a number of key enzymes
such as cyclooxygenase [9], protein kinase C [10], protein
tyrosine kinases [11] and a Ca
2þ
-dependent endonuclease
[12]. Many of these...
... permeability studies
The effect of 2-APB on membrane permeability was
monitored by assessing the quenching of calcein dye trapped
in egg phosphatidylcholine liposomes by Co
2+
, as described
by Longland ... inhibition of SERCA (Eur. J. Biochem. 269) 3687
Inhibition of SERCA Ca
2+
pumps by 2-aminoethoxydiphenyl borate
(2-APB)
2-APB reduces both Ca
2+
binding and phosphory...
... with clinically and pathologically proven steatosis
and 98 patients without steatosis were recruited into this study. The levels of fasting blood
glucose (FBG), fasting insulin (FINS), triglyceride ... levels
of serum alanine aminotransferase (ALT). The higher
prevalence of hepatic steatosis in Hispanics was
mainly due to the higher prevalence of obesity and
insulin resistance...
... contributing to the efficacy of combination LAM and HBIG remain poorly defined.
Postulated mechanisms include the synergy of: 1) LAM reducing HBV replication and altering synthesis of HBsAg necessary ...
finding of circulating HBV DNA by PCR in 2 of 11 receiving HBIG and 5 of 10 receiving LAM suggests that reinfection would be
likely in additional patients with longer obse...
... Similarly, replacing
Tyr308 with other aromatic amino acids only slightly affects
the inhibition by Zn-ferrocyanide on the enzyme. In
contrast, replacing Tyr308 with glycine or serine consider-
ably ... Zn-ferrocyanide.
Effect of Fld on the inhibition of FNR activities
by Zn-ferrocyanide
In some photosynthetic systems, such as that of certain
algae and cyanobacteria, the FMN...