Báo cáo Y học: Toxicity of novel C-terminal prion protein fragments and peptides harbouring disease-related C-terminal mutations pdf
Báo cáo Y học: Toxicity of novel C-terminal prion protein fragments and peptides harbouring disease-related C-terminal mutations pdf
... University, UK; 2 Institute of Molecular Biology and Biophysics, ETH-Hoeneggerberg, Zu ¨ rich, Switzerland Mice expressing a C-terminal fragment of the prion protein instead of wild-type prion protein ... methyl ester had only a minor effect on the toxicity of the protein. Addition of microglia had no signifi- cant effect on the toxicity of PrP121– 231. These resul...
Ngày tải lên: 31/03/2014, 23:20
Tài liệu Báo cáo Y học: Toxicity of substrate-bound amyloid peptides on vascular smooth muscle cells is enhanced by homocysteine docx
... 1–2 h after plating. Cytotoxicity assay Release of the cytoplasmic enzyme lactate dehydrogenase into the culture medium was used as a measure of cytotoxicity. Lactate dehydrogenase was determined ... University of Heidelberg, Heidelberg, Germany; 4 The School of Chemistry, The University of Melbourne, Parkville, Victoria, Australia The main component of cerebral amyloid angiopathy...
Ngày tải lên: 22/02/2014, 07:20
Báo cáo y học: "Management of chest pain: exploring the views and experiences of chiropractors and medical practitioners in a focus group interview"
... obtained directly from the source provider, and that history, exam, and differential diagnosis are central to the provision of portal -of- entry primary care as well as secondary specialty care. They noted ... questions with no easy answers, especially given the inherent high-risk, uncertainty, and complexity of chest pain diagnosis, and the possibility that chest pain may present...
Ngày tải lên: 25/10/2012, 10:06
Báo cáo y học: " Introduction of Medical Emergency Teams in Australia and New Zealand: a multi-centre study"
... Emergency Team (MET) system. • The introduction of such systems in ANZ occurred mostly before any publications reporting the possible effectiveness of such systems. • The introduction of MET systems ... first year of data as baseline and the second year as comparator. Finally, an additional and similar analysis was performed for hospitals that had partici- pated in the MERIT st...
Ngày tải lên: 25/10/2012, 10:35
Báo cáo y học: "Prevalence of Overactive Bladder, its Under-Diagnosis, and Risk Factors in a Male Urologic Veterans Population"
... Tran 1 , Martin H Bluth 2 1. SUNY Downstate Medical School, Department of Urology, Brooklyn, NY, USA 2. Wayne State University School of Medicine, Department of Pathology , Detroit, MI, USA Corresponding ... treated for urinary symptoms (OAB, LUTS and/ or BPH). Fur- thermore, those with OAB had a worse quality of life score. Mean quality of life score for those with OAB was...
Ngày tải lên: 25/10/2012, 11:35
Báo cáo Y học: Role of conserved residues within helices IV and VIII of the oxaloacetate decarboxylase b subunit in the energy coupling mechanism of the Na+ pump ppt
... well-characterized member of the sodium ion transport decarboxylase family of enzymes, which also includes methylmalonyl-CoA decarboxylase, malonate decarboxylase and glutaconyl-CoA decarboxylase from various ... the dimension of cooperativity. Experimental data for the inhibitory effect of Na + werefittedtoan exponential decay. Effect of Na + on tryptic hydrolysis of the oxaloac...
Ngày tải lên: 08/03/2014, 23:20
Báo cáo Y học: Secretion of a peripheral membrane protein, MFG-E8, as a complex with membrane vesicles A possible role in membrane secretion pptx
... mutants of MFG-E8 were expressed in COS-7 cells. The immunofluo- rescent s taining o f i ntracellular and cell-surface proteins and biochemical analyses of cell-surface-biotinylated and secre- ted proteins ... and bovine MFG-E8 proteins expressed in mammary gland were shown t o be composed of two isoforms [ 3,9]. In mouse, a Pro/Thr-rich domain is inserted possibly by a mammary g...
Ngày tải lên: 24/03/2014, 03:21
Báo cáo khoa học: Characterization of novel sequence motifs within N- and C-terminal extensions of p26, a small heat shock protein from Artemia franciscana potx
... oligomerization and subunit dynamics [8–14], and on the other by a poorly conserved, charged, highly flexible, C-terminal exten- sion active in oligomer formation, promotion of solu- bility and chaperoning ... Protein Eng 16, 847–851. 9 Wintrode PL, Friedrich KL, Vierling E, Smith JB & Smith DL (2003) Solution structure and dynamics of a heat shock protein assembly probed...
Ngày tải lên: 30/03/2014, 20:20
Tài liệu Báo cáo Y học: Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation ppt
... Ventura 1,2 1 Department of Biomedical Sciences, Division of Biochemistry, Laboratory of Cardiovascular Research, 2 Division of Cell Biology, National Institute of Biostructures and Biosystems, and 3 Department of ... mediated, at least in part, by G -protein coupled receptors (GPCRs), stimulation of membrane phospholipid hydrolysis, and activation of the diacylglycerol...
Ngày tải lên: 21/02/2014, 01:21
Tài liệu Báo cáo Y học: Characterization of a novel silkworm (Bombyx mori ) phenol UDP-glucosyltransferase potx
... UDP-glucosyltransferase gene, Bmugt1 ,and analysis of the activity of the enzyme towards a range of Correspondence to D. R. O’Reilly, Department of Biology, Imperial College of S cience, Technology and ... ith a specific enz yme activity. Keywords: Bombyx mori; detoxication; insect; UDP- glycosyltransferase. The UDP-glycosyltransferases ( UGTs) are a superfamily of enzymes that...
Ngày tải lên: 22/02/2014, 04:20