Báo cáo Y học: Exploring the primary electron acceptor (QA)-site of the bacterial reaction center from Rhodobacter sphaeroides Binding mode of vitamin K derivatives pptx

... Hucke et al.(Eur. J. Biochem. 269) Ó FEBS 2002 Exploring the primary electron acceptor (Q A )-site of the bacterial reaction center from Rhodobacter sphaeroides Binding mode of vitamin K derivatives Oliver ... 1Õ), displaying the smallest value of the binding free energy, was considered for further analysis. The binding site of the primar...

Ngày tải lên: 31/03/2014, 21:21

... G261A/ Y2 69A designed on the basis of side-chain packing criteria from a modelled structure of the enzyme resulted in restor- ation of the energy of activation to the levels of the native enzyme ... and the mutant can proceed with the catalysis as efficiently as the wild type (Fig. 3A). Investigation of the three-dimensional homology-based model of the enz...

Ngày tải lên: 22/02/2014, 04:20

Ngày tải lên: 25/10/2012, 10:02

... necessary to prevent the reappearance of this influenza. Unlike the typical “flu” that strikes the very young, chronically ill and elderly; this flu would attack and kill healthy young adults. ... reservoirs.[4,5] The common denominator in every influenza outbreak was its ability to follow the travel routes from city to city and sicken large numbers quickly and killing t...

Ngày tải lên: 02/11/2012, 11:12

... ophthalmology, dermatology, dentistry and rheumatology [10,11]. Based up on these data the aim of this study was to observe the potential of Esterified Hyaluronic Acid (EHA) as a coadjuvant of grafting ... Department of Dental Sciences and Surgery, University of Bari, Bari, Italy.  Correspondence to: Prof. F.R. GRASSI, Professor and Dean, Department of Dental Sciences...

Ngày tải lên: 03/11/2012, 11:35

... Ruk S retains only the C-terminal coiled-coil region. Although the precise role of this Ruk/CD2AP family is still unknown, they are involved in the control of apoptosis and the regulation of cytoskeletal ... an inhibitory effect on the activity of PtdIns-3 kinase. The mechanism by which PtdIns-3 kinase could be released from the inhibitory complex with Ruk L is still u...

Ngày tải lên: 17/03/2014, 23:20

... how some of these interactions are affected by a mutation in the SH2 domain of Shb, and consequently how the activation of JNK is affected. To further study the effects of the mutation in the Shb SH2 ... in proximity with the ZAP70 tyrosine kinase, the main phosphate-donor and thus activator, of these signaling proteins. These interactions are then of importance for...

Ngày tải lên: 24/03/2014, 04:21

... block by ikitoxin and birtoxin could be completely blocked by the addition of tetrodotoxin (Fig. 5). The similarity of this blocking pattern to effects reported elsewhere suggests that binding of ... °C). Molecular modeling The SWISS - PDB VIEWER software from the EXPASY server (http://www.expasy.ch) was used to visualize and compare the effect of the substitution of...

Ngày tải lên: 31/03/2014, 08:20

... His92 acts as the general acid and Glu58 as the general base during the first step of the reaction. The hydrolysis of the cyclic derivative is performed by the same groups, but their roles are ... by using the dinucleotide ApA as substrate [18]. Both mutant variants hydrolysed ApA. They displayed a K m value similar to that of the wild-type protein although they exhi...

Ngày tải lên: 31/03/2014, 23:20

... purchased from Tokyo Kasei Kogyo (Tokyo, Japan), meat extract (Extract Ehlrich) was from Kyokuto Seiyaku Kogyo (Osaka, Japan) and 4-aminoresorcinol hydrochloride was from Aldrich (Milwaukee, Wis., ... dioxygenase; 4-amino-3-hydroxybenzoate 2,3-dioxygenase. Dioxygenases catalyzing the fission of benzene rings are key enzymes in the microbial metabolic pathways of aromatic compound...

Ngày tải lên: 21/02/2014, 01:21