Báo cáo khoa học: "Co-evolution of Language and of the Language Acquisition Device" docx

... for extracellular ligands in the pericellular environment [15] (Fig. 2). The remaining portion of the membrane- bound receptor loses its ability to bind ligands, and can be further processed by the presenilin ... hydrophobic environment (mainly between Leu403 and Val404) of the phospholipid bilayer of the membrane [17]. In turn, there is decreased plasma membrane targeti...

Ngày tải lên: 15/03/2014, 23:20

... sets L p and L n of known Positive and Negative terms, respectively, and expands them into the two final training sets T r p ⊃ L p and T r n ⊃ L n by adding them new sets of terms U p and U n found ... orien- tation) is given by the sum of the weights of its semantic association with the seed positive terms minus the sum of the weights of its semantic as- soci...

Ngày tải lên: 17/03/2014, 22:20

... entry of fatty acid into mitochon- dria. Thus, the steady-state level of malonyl-CoA in these tissues is determined by the relative activities of ACC and malonyl-CoA decarboxylase. Role of the ... ghrelin and adiponectin alter hypothalamic AMPK and malo- nyl-CoA levels [13,23,28,30–33]. The genetic evidence for the role of AMPK in the hypothalamus is less clear bec...

Ngày tải lên: 14/02/2014, 22:20

... molecule takes the position of the adenine ring of ATP. The carbon and oxygen atoms of pantoate are shown in yellow and red, respectively. The carbon and oxygen atoms of ATP are shown in red, the nitrogen ... between the O2 atom of pantoate and the Nf atom of the side chain of Lys39. However, there are a large number of water-mediated networked interact...

Ngày tải lên: 16/02/2014, 09:20

... performed and the P-values are displayed, as calculated using the Student’s t-test. The mean and standard deviations of absolute numbers of the observed colonies are indicated. (C) Number of colonies ... were lysed and dilutions plated and cultured for 2 days at 27 °C. The number of colonies for OTUB1 and the OTUB1 mutants were counted and presented relative to...

Ngày tải lên: 16/02/2014, 15:20

... 158(21) and 296(154) [14–17]. The high specific activity of these FVIIa variants is presumably linked to a more stable burial of the N-terminus of the protease domain in the activation pocket of the ... included in the pub- lished alanine scanning mutagenesis study of FVIIa [13], and investigated the effects of the mutation on the enzymatic maturation of FVI...

Ngày tải lên: 18/02/2014, 08:20

... number of these modifications is low, the density of modifications is much the same as in the rest of the lin- ker histones. It is the shortness of the N-terminal tails Table 1. Alignment of chicken, ... studies [14–16] suggest that the linker histone is close to the dyad axis of the core particle at the entry and exit of the DNA. Similarly, the geometry...

Ngày tải lên: 18/02/2014, 08:20

... presenting the pulse of Src activity in the plane of the inactive and active fractions, s i and s 1 . If the duration of the stimulus exceeds the critical value, the trajectory in the (s i , ... conformation, the SH2 domain binds to pY i on the C-terminal tail, and the Src homology 3 (SH3) domain binds to the linker between the SH2 and kinase domains at...

Ngày tải lên: 18/02/2014, 11:20

... except WhiB2, the amino acid imme- diately after the C-terminal cysteine of the CXXC motif is proline (Fig. S6). In WhiB2 the absence of proline and therefore of the kink might not allow the protein ... conditions [15]. The rate of dis- integration was directly correlated with the duration and strength of the oxidizing environment. Similarly, in this study, th...

Ngày tải lên: 18/02/2014, 12:20

... resulted in 55% and 51% loss of the initial activities of BHLmL2 and BHAb, respectively. These results strongly suggest that Ser is involved in the catalytic activity of BHLmL2 and BHAb and are consistent ... 97% inhibition of BHLmL2 and BHAb, respectively. The influence of pH on the activities of the BH enzymes was investigated in the pH range 6–11. The pH...

Ngày tải lên: 18/02/2014, 14:20