... Rmaxstands for the maximal response, C is the concentration of a ligand, and K on is the equilibriumassociation constant. For a single-site interaction, i ¼ 1, for a two-site binding, i ¼ 2, and ... n is the number of tested ligands, SD is the standarderror, R2 is the correlation coefficient. This correlationimplies the direct relationship between the ligand bindingaffinity and the thermal ... designed and modified for the treatment of cardiovascular and diabetesdiseases [2]. Therefore, PPARc is an attractive target for new drug discovery.Ligand binding to PPARc is responsible for controllingthe...