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Báo cáo khoa học: Redox reaction between amino-(3,4-dihydroxyphenyl)methyl phosphonic acid and dopaquinone is responsible for the apparent inhibitory effect on tyrosinase doc

Báo cáo khoa học: Redox reaction between amino-(3,4-dihydroxyphenyl)methyl phosphonic acid and dopaquinone is responsible for the apparent inhibitory effect on tyrosinase doc

Báo cáo khoa học: Redox reaction between amino-(3,4-dihydroxyphenyl)methyl phosphonic acid and dopaquinone is responsible for the apparent inhibitory effect on tyrosinase doc

... wouldfavor the redox reaction between dopaquinone and the phosphonic diphenol. Because of the irreversibility of the systems (cyclization of dopaquinone and decomposition of the phosphonic o-quinone) the ... Redox reaction between amino-(3,4-dihydroxyphenyl)methyl phosphonic acid and dopaquinone is responsible for the apparent inhibitory effect on tyrosinase Beata G ˛asowska1, ... not veryprecise (150 mV for Dopa and 195 mV for compound 1),but indicate that the formation of the phosphonic o-quinone is not favored. Thus, two other factors drive the reaction: much slower...
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Báo cáo khóa học: Binding analyses between Human PPARc–LBD and ligands Surface plasmon resonance biosensor assay correlating with circular dichroic spectroscopy determination and molecular docking ppt

Báo cáo khóa học: Binding analyses between Human PPARc–LBD and ligands Surface plasmon resonance biosensor assay correlating with circular dichroic spectroscopy determination and molecular docking ppt

... Rmaxstands for the maximal response, C is the concentration of a ligand, and K on is the equilibriumassociation constant. For a single-site interaction, i ¼ 1, for a two-site binding, i ¼ 2, and ... n is the number of tested ligands, SD is the standarderror, R2 is the correlation coefficient. This correlationimplies the direct relationship between the ligand bindingaffinity and the thermal ... designed and modified for the treatment of cardiovascular and diabetesdiseases [2]. Therefore, PPARc is an attractive target for new drug discovery.Ligand binding to PPARc is responsible for controllingthe...
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Tài liệu Báo cáo khoa học: Mechanism of dihydroneopterin aldolase NMR, equilibrium and transient kinetic studies of the Staphylococcus aureus and Escherichia coli enzymes docx

Tài liệu Báo cáo khoa học: Mechanism of dihydroneopterin aldolase NMR, equilibrium and transient kinetic studies of the Staphylococcus aureus and Escherichia coli enzymes docx

... ran the forward reaction (the formation of HP) using both DHNP and DHMP as the substrates and the reverse reaction (the formation of DHNP and DHMP) with HP and GA. For the forward reaction, three ... variousforms in solution and only a small fraction is in the correct form for the reaction [19,20]. To furtherinvestigate the issue of the reversibility of the DHNA-catalyzed reaction, we ran the ... mechanism for the epimerization reaction. Equilibrium binding studiesAs the epimerase reaction uses the same reaction inter-mediate as that of the aldolase reaction and the aldo-lase reaction is...
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Tài liệu Báo cáo khoa học:

Tài liệu Báo cáo khoa học: "A Large Scale Distributed Syntactic, Semantic and Lexical Language Model for Machine Translation" doc

... the 49th Annual Meeting of the Association for Computational Linguistics, pages 201–210,Portland, Oregon, June 19-24, 2011.c2011 Association for Computational LinguisticsA Large Scale Distributed ... and TAGGERoperations, some hypotheses are discarded due to the maximum number of hypotheses the stack cancontain at any given time. In CONSTRUCTORoperation, the resulting hypotheses are discardeddue ... much as possible, this is Reduce.of the servers by hashing through the word w−1(orh−1) and its topic g, finish the Reduce part. This is the initialization of the N-best list approximateEM...
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Báo cáo khoa học: ATP-binding domain of heat shock protein 70 is essential for its effects on the inhibition of the release of the second mitochondria-derived activator of caspase and apoptosis in C2C12 cells potx

Báo cáo khoa học: ATP-binding domain of heat shock protein 70 is essential for its effects on the inhibition of the release of the second mitochondria-derived activator of caspase and apoptosis in C2C12 cells potx

... of HSP70 is essential for the inhibitionof H2O2-induced activation of caspases-9 and -3 and apoptosis. (A) The effects of HSP70 and its deletion mutant proteins on the acti-vation of caspases-9 ... apoptosis. The role of the ATP-binding domain of HSP70in the prevention of the release of Smac and apoptosis after exposure to H2O2To determine which region of HSP70 is responsible for its ... which comprises amechanism that involves the inhibition of Smac releasefrom mitochondria, and the suppression of caspaseactivation. Such a mechanism is independent of the interaction of HSP70...
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Báo cáo khoa học:

Báo cáo khoa học: "A Freely Available Morphological Analyzer, Disambiguator and Context Sensitive Lemmatizer for German" pdf

... Lexical System The lexicon of Morphy is very compact as it only stores the base form for each word together with its inflection class. Therefore, the complete morphological information for 324,000 ... lemmata for each word form. Secondly, the tagger determines the grammatical categories of the word forms. If, for any of the lemmata, the inflected form corre- sponding to the word form in the ... number of word forms in the text, the accuracy is 99.2% for the large and 99.3% for the small tag set. The better performance when using the small tag set is somewhat surprising since there are...
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Báo cáo khoa học: Alternative splicing produces an H-protein with better substrate properties for the P-protein of glycine decarboxylase doc

Báo cáo khoa học: Alternative splicing produces an H-protein with better substrate properties for the P-protein of glycine decarboxylase doc

... essential for photorespiratory and one-carbonmetabolism, and the vital function of this enzymecomplex is indicated by the fact that its inactivation is fatal to plants [4] and animals [5]. The GDC ... assayconditions may be closer to the situation in C4leafmitochondria, which contain distinctly less GDC, and even closer to that of root mitochondria.Furthermore, it is not known whether alternativesplicing ... Although this is not avery large effect, it could have significance for both C3 and C4plants in vivo. For C3plants, this may beassumed from effects on photosynthesis observed afterantisense...
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Báo cáo khoa học: Large-scale overproduction, functional purification and ligand affinities of the His-tagged human histamine H1 receptor ppt

Báo cáo khoa học: Large-scale overproduction, functional purification and ligand affinities of the His-tagged human histamine H1 receptor ppt

... such as visual and olfactory perception, hormone action, neurotransmis-sion, growth and differentiation control. GPCRs thereforerepresent major therapeutic targets.Histamine has one of the broadest ... This dual effect of both stabilizing and estimating functional receptors greatly facilitated the optimization of conditions for solubilization, purification and reconstitution. For solubilization ... purification. On the one hand it is essential for purification, while on the other hand it destabilizes the receptor, resulting in a time-dependent loss of functional properties. The kinetics ofthis...
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Báo cáo khoa học:

Báo cáo khoa học: "Complementing Word Net with Roget''''s and Corpus-based Thesauri for Information Retrieval" pdf

... a form of comparison between doc- uments and queries. In traditional IR methods, this comparison is done based on the use of com- mon index terms in the document and the query (Salton and ... a query and on the sim- ilarity between the terms, and ranges from 0 to 1. The weight of an expansion term depends both on the entire query and on the similarity between the terms. The weight ... of the vocabulary. 2.3.2 Syntactically-based Thesaurus In contrast to the previous section, this method attempts to gather term relations on the ba- sis of linguistic relations and not document...
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Tài liệu Báo cáo khoa học: Loose interaction between glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate kinase revealed by fluorescence resonance energy transfer–fluorescence lifetime imaging microscopy in living cells doc

Tài liệu Báo cáo khoa học: Loose interaction between glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate kinase revealed by fluorescence resonance energy transfer–fluorescence lifetime imaging microscopy in living cells doc

... with the sequence SGLRSRAQASNS. The tetramericstructure of GAPDH is schematically shown on the right. The distances between the N-terminal amino acids of subunits O and P,subunits O and Q and ... life-time as that of the FRET component in the donorcurve (M. Takada et al., unpublished observation).Besides glycolysis and gluconeogenesis, GAPDH and PGK have different functions in the nucleus. ... 1.0–1.1a The differences between the two s1values and the two s2values were significant (P < 0.005 for s1 and P < 0.001 for s2).b The differences between the two s1values and the two...
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