Báo cáo khoa học: Structural requirements for the apical sorting of human multidrug resistance protein 2 (ABCC2) potx

... cture of n NOS-syntrophin complex. Science 28 4, 8 12 815. 1876 A. T. Nies et al. (Eur. J. Biochem. 26 9) Ó FEBS 20 02 Structural requirements for the apical sorting of human multidrug resistance protein ... part of MRP2 contains information for apical sorting of MRP2. Apical localization of GFP–MRP2 in polarized HepG2 and MDCKII cells A s equence ali...

Ngày tải lên: 31/03/2014, 09:20

... 6 421 28 22 0 12 Tel: +49 0 6 421 28 22 0 32 E-mail: essen@chemie.uni-marburg.de; marahiel@staff.uni-marburg.de (Received 31 March 20 09, revised 30 April 20 09, accepted 5 May 20 09) doi:10.1111/j.17 42- 4658 .20 09.07085.x The ... deposited in the Research Collaboratory for Structural Bioinformatics under accession numbers 2WBO for the substrate•tar- trate•iron complex,...

Ngày tải lên: 16/03/2014, 02:20

... Universidad 20 01, Col Chamilpa, Cuernavaca, Mor. 622 70, Mexico Fax: + 52 731 723 88 Tel: + 52 5 55 66 22 76 63 E-mail: yvonne@ibt.unam.mx (Received 29 April 20 08, revised 11 June 20 08, accepted 16 June 20 08) doi:10.1111/j.17 42- 4658 .20 08.06554.x Dermaseptin ... a surface area of approximately 5 nm 2 ; in the b-structure formation, the peptide has a contact area of 1...

Ngày tải lên: 23/03/2014, 07:20

... 2. 85 ⁄ 2. 78 2. 85 ⁄ 2. 75 2. 78 ⁄ 2. 77 2. 75 ⁄ 2. 84 Gly106(N) Man(O3) 2. 86 ⁄ 2. 94 2. 97 ⁄ 2. 99 2. 83 ⁄ 2. 80 2. 96 ⁄ 2. 84 Asn138(ND2) Man(O4) 3.00 ⁄ 2. 92 2.93 ⁄ 2. 93 2. 95 ⁄ 2. 93 3.15 ⁄ 2. 98 Glu 221 (N) ... statistics. Ligand- removed Mannose GlcNAc (b1 2) Man GlcNAc(b1 2) Man (a1–3)ManOMe M5 92 NA2F Space group P2 1 2 1 2 1 P2 1 2 1 2 1 P2 1 2...

Ngày tải lên: 23/03/2014, 11:20

... side of the dimer surface, and extends the b-sheet dimer interface. Residues R 421 –C 427 of the GRINL1A peptide adopt a b-strand conformation as assumed by residues K 229 –V235 of nNOS peptide, and the ... area. Figure 4A shows the 20 lowest-energy conformers from the selected cluster modelled using the Haddock docking calculations. The rmsd values for the 20 low...

Ngày tải lên: 29/03/2014, 09:20

... at the 2 or 3¢ oxygen of m 7 Guo The kinetic parameters obtained for m 2 7 ,2 -O GpppG and m 2 7,3¢-O GpppG demonstrated the crucial role of the 2 -OH and 3¢-OH groups of the m 7 Guo moiety for C. ... 0.18 3. 12 ± 1.45 5.09 ± 2. 80 bn 7 GpppG bn 7 GMP + GDP 1.83 ± 0.15 3.06 ± 0. 12 1.67 ± 0.15 m 3 2, 2,7 GpppG m 3 2, 2,7 GMP + GDP 3.85 ± 0.41 4.65 ± 0 .26 1 .21...

Ngày tải lên: 29/03/2014, 09:20

... K 0.5 of the mutants compared to k cat ⁄ K 0.5 of Dm-dNK (-fold) dT N45D 0.9 5.3 1 2. 6 2. 9 · 10 6 4.1 N64D 23 .2 1.7 0.8 0. 82 35344 473 N45D ⁄ N64D a 24 .2 2.5 1 1 .22 50000 24 0 Wildtype b 1 .2 29.5 ... 6 N64D 3 820 0. 82 0.9 0.4 105 876 N45D ⁄ N64D a 3166 1.7 1 0. 828 26 0 354 Wildtype b 22 5 42. 7 1 20 .6 920 00 1 dG N45D 4 12 2.7 1 1.3 3155 7.3 N64D 20 350 0 .24 0....

Ngày tải lên: 30/03/2014, 20:20

... NAD + -dependent D -2- hydroxyisocaproate dehydrogenase. FEBS Journal 27 2 (20 05) 26 9 28 1 ª 20 04 FEBS 26 9 (Prelog–Helmchen Re ⁄ Si-system [5]), at the C4N atom of the nicotinamide moiety of the reduced ... a resolution of 1.98 A ˚ . The structural analysis of HGDH together with the comparison with other structurally characterized members of the D -2- hydroxy...

Ngày tải lên: 23/03/2014, 13:20

... eliminate the cause of the incorrect translation. Before the account of the program itself we give a short sketch of the considerations which led to the program, to- gether with a statement of the ... letting the sequence translate as the sequence (in the same order) of the translations of the symbols. The fact that there are only finitely many sym...

Ngày tải lên: 23/03/2014, 13:20

... interested in the computational properties of either kind of language, we will be interested in their language-theoretic properties, as well as properties of the grammars that define them and the parsers ... undeclared vari- ables make no sense either to the compiler or to the CPU. But they are still programs, provided they conform in all other ways to the syntax of...

Ngày tải lên: 24/03/2014, 01:21