Báo cáo Y học: Optimizing the delivery systems of chimeric RNA DNA oligonucleotides Beyond general oligonucleotide transfer ppt
Báo cáo Y học: Optimizing the delivery systems of chimeric RNA . DNA oligonucleotides Beyond general oligonucleotide transfer ppt
... REVIEW ARTICLE Optimizing the delivery systems of chimeric RNA . DNA oligonucleotides Beyond general oligonucleotide transfer Li Liang, De-Pei Liu and Chih-Chuan Liang National Laboratory of Medical ... with the development of delivery systems can RDOs be used for gene therapy, and successfully applied to functional genomics. Keywords: chimeric RNA DNA...
Ngày tải lên: 31/03/2014, 08:20
Báo cáo Y học: Monitoring the structural consequences of Phe12 fi D-Phe and Leu15 fi Aib substitution in human/rat corticotropin releasing hormone Implications for design of CRH antagonists pdf
... shows the family of 40 structures and Table 1 contains a summary of statistical data indica- ting the quality of the 40 models and the average energy- minimized structure. The polypeptide chain of ... Cordopatis Department of Pharmacy, University of Patras, Greece A new human/rat CRH analogue has been synthesized using the Fmoc/tBu solid-phase synthetic protocol. The...
Ngày tải lên: 17/03/2014, 10:20
Báo cáo Y học: Expanding the scorpion toxin a-KTX 15 family with AmmTX3 from Androctonus mauretanicus pptx
... occlude channels by binding to the outer opening of the conduction pore, at the centre of symmetry of the channel [2–6]. Two new toxins blocking transient A-currents were recently isolated from ... (Applied Biosystem) using a-cyano-4-hydroxycin- namic acid as matrix. Lethality assay in mice The in vivo toxicity of venoms, HPLC fractions or purified toxins was tested in male C...
Ngày tải lên: 23/03/2014, 21:20
Báo cáo Y học: Reconstructing the replication complex of AcMNPV pdf
... with 2 lg of the reporter plasmid pCAPCAT, and either 0.5 lg of each of the clones of the overlapping AcMNPV k library or 1.0 lg of each plasmid of the overlapping lef library as described by Passarelli ... by insertion of PCR products into the BglII and PspAI sites of plasmid phsp70HAHisVI+ containing the 5¢ terminal amino acid sequence RYPYDVPDYARA. The sequenc...
Ngày tải lên: 23/03/2014, 21:20
Báo cáo y học: "A prospective observational study of the relationship of critical illness associated hyperglycaemia in medical ICU patients and subsequent development of type 2 diabetes"
... commonly complicated by hyperglycaemia caused by mediators of stress and inflammation. Severity of disease is the main risk factor for development of hyperglycaemia, but not all severely ill ... for tendency to hyperglycaemia that are the root of hospital acquired hyperglycaemia and in the long term lead to development of diabetes. Although the incidence of hospital acqui...
Ngày tải lên: 25/10/2012, 10:02
Báo cáo y học: "Facing medical care problems of victims of sexual violence in Goma/Eastern Democratic Republic of the Congo"
... assessment of the availability of key resources to treat victims of sexual vio- lence in hospitals regularly caring for victims of sexual violence; and (3) assessment of the frequency of delivery of ... violence in the four hospitals of Goma. Only half of the hospitals had physicians specialized in gynaecology or gynaecological surgery available. Similarly, anaesth...
Ngày tải lên: 25/10/2012, 10:06
Báo cáo y học: "Demonstrating the benefit of medical emergency teams (MET) proves more difficult than anticipated"
... by use of regular reminders until the first day of the study period. The staff designated to form the MET varied between participating centers because of local circumstances. The study protocol ... criteria and who were subsequently admitted to the ICU. During the study, there were no differences in the incidence of the composite primary outcome between the con...
Ngày tải lên: 25/10/2012, 10:39
Báo cáo y học: " Derivation and preliminary validation of an administrative claims-based algorithm for the effectiveness of medications for rheumatoid arthritis"
... the potentially limited generalizability of patterns of care in the VHA system and possible dissimilarity in the RA patients it treats compared to other RA populations. However, sensitivity ... patients and generally continued even if therapeutic response is suboptimal, in contrast to other RA therapies where the drugs are typically discontinued if they are not effective. Becau...
Ngày tải lên: 25/10/2012, 10:45
Báo cáo y học: " Introducing the Critical Care Forum’s ongoing review of medical statistics"
... the management of patients have a sound grasp of at least the basics of statistical methods. Unfortunately, in practice this is often not true, with many relying on distant memories of poorly ... Although some of the topics covered in this series will probably be familiar, it is hoped that there will still be useful lessons to be learned, for example the underlying assumptio...
Ngày tải lên: 25/10/2012, 10:45
Báo cáo y học: "A Comparative Effectiveness Study of Bone Density Changes in Women Over 40 Following Three Bone Health Plans Containing Variations of the Same Novel Plant-sourced Calcium"
... unacceptable by the end of the study. In all three groups and sub-groups, none of the normal scores were abnormal by the end of the study. Thus, it was our conclusion that the absence of changes in the ... repeated measures of total bone density phantoms provided by the manufacturer. Outcome Measure of safety. To assess safety in all three Plans at baseline a...
Ngày tải lên: 25/10/2012, 11:10