Báo cáo Y học: Modulation of inositol 1,4,5-triphosphate concentration by prolyl endopeptidase inhibition ppt
Báo cáo Y học: Modulation of inositol 1,4,5-triphosphate concentration by prolyl endopeptidase inhibition ppt
... Kerenyi, T.D. (1971) Leucylglycinamide released from oxytocin by humanuterine enzyme. Science 173, 827–829.35. Shinoda, M., Miyazaki, A. & Toide, K. (1999) Effect of a novel prolyl endopeptidase ... 9H-fluorenyl-9-ylmethylN-[2-(2-cyano-1-pyrrolidinyl)-1-methyl-2-oxoethyl]carbamate;NHMec, 7-(4-methyl)coumarylamide; PEP, prolyl endopeptidase. Enzyme: prolyl endopeptidase (EC 3.4.21.26).(Received 16 July 2002, revised 20 September ... Modulation of inositol 1,4,5-triphosphate concentration by prolyl endopeptidase inhibition Ingo Schulz1, Bernd Gerhartz1, Antje Neubauer1,...
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Báo cáo Y học: Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules pptx
... Kinetics of inhibition of human immunodeficiency virus type 1 (HIV-1)reverse transcriptase by the novel HIV-1-specific nucleosideanalogue [2¢,5¢-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofurano-syl]-3¢-spiro-5¢-(4¢-amino-1¢,2¢-oxathiole-2¢,2¢-dioxide) ... of HIV-1 PRThr-Val-Ser-Tyr-Glu-Leu-OH 12 Kinetic analysis [20]Palmitoyl-Thr-Val-Ser-Tyr-Glu-Leu-OH 0.5 Kinetic analysis [20]Palmitoyl-Tyr-Glu-Leu-OH 0.15 Kinetic analysis [21]Palmitoyl-Tyr-Glu-(L-threonine)-OH ... [41,44].N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthaldehydehydrazone (BBNH) is a multitarget inhibitor of HIV-1 RTthat binds to both the DNA polymerase and RNase Hdomains of the enzyme, and inhibits both enzymaticactivities...
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Báo cáo y học: "Extension of the PNA world by functionalized PNA monomers eligible candidates for inverse Diels Alder Click Chemistyr"
... subsequently desiccated. 2 Coupling of the Fmoc-C2-glycine-tert-butyl ester with the Reppe anhydride: 2 mmol of the Fmoc-C2-glycine-tert-butyl ester 9 and 4 mmol N,N-diisopropylethylamine ... acetic ether were used at the ratio of 2:1. The purity was estimated by use of thin-layer chromatography. Cleavage of the tert-butyl ester. 2 mmol tert-butyl pro-tected PNA building block functionalized ... Theory of 1,3-Dipolar Cycloadditions. In: Padwa A, editor. 1,3-Dipolar Cycloaddition Chemistry. New York: Wiley; 1984: 1-176. 5. Lin FL, Hoyt HM, van HH, et al. Mechanistic investigation of...
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Tài liệu Báo cáo khoa học: Modulation of a-synuclein aggregation by dopamine in the presence of MPTP and its metabolite pptx
... Theimportance of hydrophobic interactions in the aggrega-tion of a-synuclein has recently been reinforced by agi-tation studies which have clearly shown the formation of amyloid-type of aggregates only ... of aggregates formed in case of a-synuclein alone and in the presence of MPTP ⁄ MPP+is different.AbbreviationsMPP, 1-methyl-4-phenylpyridinum; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; ... level of sensitivity to MPP+and pesti-cides as wild-type mice [13]. Thus, the aim of thisstudy was to delineate any direct role of MPTP in theaggregation of a-synuclein and the effect of dopamineon...
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Báo cáo Y học: Characterization of the exopolysaccharide produced by Streptococcus thermophilus 8S containing an open chain nononic acid doc
... mixtures of methyl glycosides were analyzed onGLC [14,15]. The absolute configurations of the monosac-charides were determined by GLC analysis of the trimeth-ylsilylated (–)-2-butyl glycosides ... neutralizationand removal of boric acid by coevaporation with methanol,the mixture of partially methylated alditols was acetylatedwith acetic anhydride (3 h, 120 °C), and analyzed by GLCand GLC–EIMS ... analysis samples were subjected tomethanolysis (methanolic 1MHCl, 18 h, 85 °C), followed by re-N-acetylation and trimethylsilylation (1 : 1 : 5 hexa-methyldisilazane-trimethylchlorosilane-pyridine),...
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Báo cáo khoa học: Modulation of the endocannabinoid system by focal brain ischemia in the rat is involved in neuroprotection afforded by 17b-estradiol pdf
... Neuropharmacology,Laboratory of Neurochemistry, Rome, Italy4 Laboratory of Pathophysiology of Integrative Autonomic Systems, IRCCS Neurological Institute C. Mondino Foundation and UniversityCentre ... levels of the endocannabinoid anandamide, and the activities of the synthesizing and hydrolyzing enzymes, i.e. N-acylphosphatidyletha-nolamine-hydrolyzing phospholipase D and fatty acid amide hydrolase,respectively, ... Department of Pharmacobiology and University Center for the Study of Adaptive Disorder and Headache (UCADH),Section of Neuropharmacology of Normal and Pathological Neuronal Plasticity, University of...
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Báo cáo Y học: Regulation of mammalian translation factors by nutrients pot
... Thr70, the sites most profoundlyaffected by rapamycin, may be regulated by nutrientsthrough the mTOR pathway.REGULATION OF 4E-BP1 BY AMINOACIDSIn a number of kinds of mammalian cells, amino ... thecontrol of eIF4E (by 4E-BP1) for the activation of proteinsynthesis by amino acids [92]. In isolated rat heart cells(ventricular myocytes), protein synthesis is acutely activated by insulin [70] ... ribosome. Phosphorylation of eEF2 iscatalysed by eEF2 kinase, an unusual and highly specificenzyme. A more detailed discussion of eEF2 and eEF2kinase can found in the accompanying article by Browneand...
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Báo cáo Y học: Activation of a covalent outer membrane phospholipase A dimer pptx
... was stopped by the addition of 250 mMEDTA. The extent of phospholipidhydrolysis was analysed by TLC.RESULTSConstruction of a covalent OMPLA dimerThe absence of cysteines in wild-type OMPLA ... Whereas wild-type OM-PLA activity displayed high sensitivity towards the type and concentration of detergent, enzymatic activity of the cova-lent OMPLA dimer was insensitive towards any detergentused ... dimerizationthereby indirectly influencing binding of the catalyticcalcium for wild-type OMPLA.Subsequently, it was investigated whether the type of detergent in the kinetic assays had any effect on...
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Báo cáo Y học: Role of critical charged residues in reduction potential modulation of ferredoxin-NADP+ reductase Differential stabilization of FAD redox forms doc
... mV) and the maximum concentration of semiquinone stabilized by the wild-typeenzyme ([SQ] ¼ 22.4% as determined by photoreductionexperiments) are known. Thus, by simultaneously solvingthis Nernst ... as only the methylgroups of the FNR dimethylbenzene ring, proposed to bethe entry point of electrons, are exposed to the solvent [20].Replacement of E301 by Ala increases the degree of exposure ... maximalamount of only 2% of semiquinone are shown by E301AFNR (Table 1).Binding affinities of apoFNR variants for the differentredox states of FADDue to the irreversible denaturation of FNR upon...
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Báo cáo Y học: Expression of uncoupling protein-3 in subsarcolemmal and intermyofibrillar mitochondria of various mouse muscle types and its modulation by fasting docx
... detected by chemiluminescenceusing a standard ECL kit and developed Hyperfilm ECLfilm. They were quantified by scanning photodensitometryusing ImageQuant Software 3.3 (Molecular Dynamics,Sunnyvale, ... specificity of the antibody to UCP3was tested using UCP3KO muscle mitochondria, whichwere described by Gong et al. [7] and generously provided by Dr Mary Ellen Harper (University of Ottawa, ... degree of accuracy, but only if obtained on the same gel.The density of UCP3 protein (i.e. the intensity of thesignal expressed per mg of proteins) was similar in the SSmitochondria of the...
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