Báo cáo Y học: The cytoplasmic C-terminus of the sulfonylurea receptor is important for KATP channel function but is not key for complex assembly or trafficking pdf

... 269) 5313 The cytoplasmic C-terminus of the sulfonylurea receptor is important for K ATP channel function but is not key for complex assembly or trafficking Jonathan P. Giblin*, Kathryn Quinn* ... (2000) Pharmaco- topology of sulfonylurea receptors. Separate domains of the regulatory subunits of K(ATP) channel isoforms are required for se...

Ngày tải lên: 31/03/2014, 08:20

... feeling of mass in the throat she had had for two years. The patient described difficulty in swallowing. Indirect laryngoscopy did not reveal any masses at bilateral pyriform sinuses, and the mucosa ... Enzinger and Harley in 1975 2 . It is more frequently found in men between the ages of 40–60, and is a soft tissue tumor characterized by replace- ment of the matu...

Ngày tải lên: 25/10/2012, 10:51

... the height of the orbit and extends just above the top of the most-anterior ethmoid cells. By the age of 8 years, the top of the frontal sinuses is at the level of the orbital roof, and by ... Discussion The variations in the anatomy of the frontal sinus may be critical for morphological or forensic investi- gations and for neurosurgeons performi...

Ngày tải lên: 25/10/2012, 11:04

... affinity of glycopeptides to the antibody [18]. Conventional pepscan analysis however, does not allow easy analysis of the contribution of the carbohydrate portion. To assess the involvement of carbohydrates ... nonbinding bottom portion of the next Fab is formed by the C-terminal segment RPAP. The size o f the interaction surface between the peptide and the n...

Ngày tải lên: 21/02/2014, 15:20

... the phosphorylation of UTP and hydrolysis of glutamine for optimal efficiency in CTP synthesis rather than just acting to increase the rate of glutamine hydrolysis itself. Keywords: CTP synthase; isothermal ... increase the rate of glutamine hydrolysis, there would have been no effect of adding GTP when the rate of CTP synthesis was limited by the concentration of nucl...

Ngày tải lên: 21/02/2014, 15:20

... 2-arachidonoylglycerol (2-AG), the cannabinoid CB 1 and CB 2 receptors, and one of the enzymes mostly responsible for endocannabinoid hydrolysis, the fatty acid amide hydrolase (FAAH). By using a very ... observed, again in vitro [9]. The endocannabinoid system, comprising membrane receptors for THC, endogenous ligands for these receptors, and proteins for their biosynthesis...

Ngày tải lên: 22/02/2014, 07:20

... standard. Sugar analysis was carried out by gas-liquid chromatography of trimethylsilyl derivatives of methyl glycosides formed by methanolysis in 0.5 M HCl in methanol at 80 °C for 24 h [31]. Reducing sugars ... analysis is highly developed because it is a remarkable model for the study of bacterial photosynthesis [22]. R. sphaeroides shows a close relation- ship to organisms...

Ngày tải lên: 17/03/2014, 17:20

... domain 4 of the extracellular part of the receptor [28]. Therefore, analysis of the ability of the mutants gp130D4 and gp130D4 to form complexes with the LIFR by coprecipitation was not possible ... copre- cipitation of gp130 with LIFR independently of the lysis buffer used for the disintegration of the cells (data not shown). Because of the high expr...

Ngày tải lên: 18/03/2014, 01:20

... in the human Northern analysis. One possible explanation for this apparent discrepancy could be that the NICN1 expression in liver is not constantly high but dependent on the metabolic state of ... of the organ. As the RNA for the Northern blot and the RT-PCR analysis had been derived from two different anonymous human donors the differ- ences in the observed N...

Ngày tải lên: 23/03/2014, 21:20

... respectively, at 37.0 °C. This DNA cleavage was a largely exothermic reaction. The catalytic efficiency of BLM- A 5 is of the same order of magnitude as that of lysozyme but several orders of magnitude ... activated BLM, is formed [2,4,5,13,14,16,18,46]. Table 4. Comparison of the molar enthalpy change for the cleavage of calf thymus DNA induced by BLM-A 5 and thos...

Ngày tải lên: 24/03/2014, 04:21