Báo cáo Y học: Hemocyanin from the keyhole limpet Megathura crenulata (KLH) carries a novel type of N-glycans with Gal(b1–6)Man-motifs doc

... (Deisenhofen, Germany). Peptide-N 4 -(N-acetyl-b-glucosaminyl)asparagine amidase A from almond (PNGase A) was from Seikagaku (Tokyo, Japan) and b-galactosidase from jack beans was obtained from Glyco (Upper ... N-linked carbohydrate chains from H. pomatia and L. stagnalis represent mostly core xylosylated monoantennary and diantennary complex -type glycans with extended, often...

Ngày tải lên: 31/03/2014, 08:20

... adversely affect the repairing capacity and the defensive mechanism of the GI mucosae that have been damaged during chemotherapy. In this regard, AP was shown to be beneficial to cancer patients ... dampening effect of CY on VEGF expression in the gastric mucosa. These data suggest that AP is a cytoprotective agent which can protect against the cytotoxicity of CY on hema...

Ngày tải lên: 02/11/2012, 10:19

... Biosynthetic pathway leading to clavulanic acid. BLS, beta- lactam synthetase (ORF3); PAH, proclavaminate amidino hydrolase (ORF4); CAS, clavaminate synthase (ORF5); CAD, clavaldehyde dehydrogenase ... reversible transfer of an acetyl group from N-acetylornithine to glutamate, but not the formation of N-acetylglutamate from glutamate and acetyl-coenzyme A, nor (detectably) the hy...

Ngày tải lên: 08/03/2014, 22:20

... (Millipore) and then mixed with the matrix solution (a- cyano-4-hydroxy- cinnamic acid) for MALDI-TOF MS analysis. Structure comparison A search of the SwissProt-TrEMBLE database, pairwise and m ultiple ... saturated with a- cyano-4-hydroxycinnamic a cid ( CHCA) or 2 ,5-dihydroxy- benzoic acid d issolved in water. The mixture of peptide and matrix was placed on the MALDI...

Ngày tải lên: 08/03/2014, 23:20

... men and three women (all Italian), ranging from 49 to 79 years of age (mean age, 64.8 ± 7.8 years). None had any apparent distant metastasis, and none had been previously treated for HCC. The ... growth and metas- tasis. As pharmacological regulation of uPA and c-met has proved to be a challenge in cancer, this regulatory mechanism may potentially be a new tool with which to alt...

Ngày tải lên: 29/03/2014, 23:20

... amount of CYP 3A5 protein accurately as it can be affected by other factors, genetic (expression of m-RNA, stability of CYP 3A5 protein, dual metabolic pathway via CYP 3A4 and CYP 3A5 , linkage disequi- librium ... be a more accurate me- thodology for the analysis of such data but it is more demanding in the quantity of available data. In the LR analysis, the kinetic...

Ngày tải lên: 26/10/2012, 09:32

... folds, ocular hypotelorism, preauricular tags and pits, low-set ears, simian crease, clino- and camptodactyly, partial syndactyly between toes 2 and 3, hydrocele, umbilical hernia, sacral dimple, ... prevalence of congenital abnormalities is used. Of course, the total prevalence of congenital abnormalities depends on the spectrum of congenital abnormalities evaluated, the...

Ngày tải lên: 02/11/2012, 11:12

... Criteria for Assessing Applicability to Human Germline Gene Therapy An ideal gene transfer system in the context of human germline gene therapy would have the following features: (a) the ability ... rates) would there be any point in attempting the technique with humans – but the necessary data on efficiency could only come from actual attempts with humans. Another prob...

Ngày tải lên: 03/11/2012, 10:01

... demonstrate the efficacy of daraprim in the therapy of ocular toxoplasmosis. But the out- come was measured 4 weeks after initiation of ther- apy. Dihydrofolate reductase inhibitors (DHFR) have ... of ocular toxoplasmosis. The efficacy of the drug was reported in cerebral toxoplasmosis in AIDS patients. The dos- age used by Rothova et al was 250mg a day or 500mg ev...

Ngày tải lên: 03/11/2012, 11:01

... vertebrate origins. Science 298, 2157–2167. 8 Satou Y, Yamada L, Mochizuki Y, Takatori N, Kawashima T, Sasaki A, Hamaguchi M, Awazu S, Yagi K, Sasakura Y et al. (2002) A cDNA resource from the basal ... [48]. Measurement and analysis of AChE activity and inhibition Acetylcholinesterase activity was measured according to the method of Ellman et al. [49] as modified by Doctor et...

Ngày tải lên: 18/02/2014, 17:20