Báo cáo Y học: Contribution of Lys276 to the conformational flexibility of the active site of glutamate decarboxylase from Escherichia coli pptx
Báo cáo Y học: Contribution of Lys276 to the conformational flexibility of the active site of glutamate decarboxylase from Escherichia coli pptx
... Contribution of Lys276 to the conformational flexibility of the active site of glutamate decarboxylase from Escherichia coli Angela Tramonti1, Robert A. John2, ... polarity of the active site. In this hypothesis, the environment of the cofactor is more hydrated in the low-pH conformation. Thus, the increased polarity favors the 420 nm-ketoenamine tautomer in the ... [21]. The present work has been undertaken with the aim of determining the contribution of the active- site lysine residue (Lys276) to coenzyme binding and to stages in the reactioncatalysed by E....
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Báo cáo y học: "A Practical Approach to Management of Chronic Hepatitis B"
... bbiiooggrraapphh y y Ke-Qin Hu, MD, is the Director of Hepatology Services and Associate Professor of Clinical Medicine, Divisions of Gastroenterology and Transplantation, University of California, ... directly pathogenic to hepatocytes and host immune response to HBV antigens expressed on the infected hepatocytes is the principle determinants of the liver injury. Thus, a high HBV load has been the ... monitored regularly. The interval of follow-up visits may vary depending on regimen and duration of the HBV treatment. For instance, those on IFN therapy may need to be monitored every 4-6 weeks,...
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Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx
... forphosphorylation), GST–cyto -Y5 97F (Y! F mutation at the 597 position), GST– cyto -Y6 41F (Y! F mutation at the 641 position), GST– cyto -Y6 67F (Y !F mutation at the 667position), GST– cyto -Y6 91F (Y! F ... celllysates bind to a GST fusion of the cytoplasmicdomain of siglec-10. Ten micrograms of GSTalone, GST– cyto-wt and GST– cyto -Y6 67F weretyrosine phosphorylated (-P) with a mixture of Lck, ... cytoplasmic tyrosineswas evaluated by kinase assay using wild-type siglec-10cytoplasmic domain and Y! F mutants. The majority of the phosphorylation could be attributed to Y5 97 and Y6 67.Further experiments...
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Báo cáo y học: "Medical resource utilization among patients with ventilator-associated pneumonia: pooled analysis of randomized studies of doripenem versus comparators"
... Consideration of the influence of appro-priateness of empiric therapy against subsequently identi-fied pathogens was beyond the scope of this economicanalysis and merits further evaluation. The lack of ... important component of hos-pital costs. VAP adds five days to the duration of mechan-ical ventilation [1], four to six days to LOS in the ICU[2,4], and seven days to overall duration of hospitalization[1]. ... prospectively defined in the phase IIIstudy protocols. Medical resource utilization, which wasretrospectively analyzed from prospectively collecteddata in the pooled analysis, included durations of mechanical...
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Báo cáo y học: "Surgical and medical emergencies on board European aircraft: a retrospective study of 10189 cases"
... in the study. Data wereprovided from one airline for the years 2002 to 2007 and from another for 2006 to 2007. The total rpk analysed in this studyincluded a total of 613.03 billion rpk. Of ... providing therapy were analysed.Results Only four airlines, of which two participated in thisstudy, were able to provide the necessary data. A total of 10,189 cases of IMEs were analysed. Syncope ... werealso obtained from the individual airlines. rpk is a measure of the volume of passengers carried by an airline; it is the sum of the products obtained by multiplying the number of revenuepassengers...
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Báo cáo y học: "Maternal Outcomes According to Placental Position in Placental Previa"
... And then they are com-pared to each other. Logistic regression was used to control for confounding factors. Results: In the anterior group, regardless of confounding factors, the incidence of ... all patients. To compare maternal outcomes, the hemoglobin level of prior to surgery, 1 day after surgery, and 3 days after surgery, the amount of transfusion during surgery, estimated blood ... parity, delivery methods, maternal past history (miscarriage, uterine surgery), diseases asso-ciated with pregnancy (myoma, endometriosis), pre-natal ultrasonography and the findings of surgery...
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Báo cáo y học: "980 nm diode lasers in oral and facial practice: current state of the science and art"
... the suggestions of scientific literature on the advantages of the compactness, reliability, ease of use and affordability of the 980 nm Diode Lasers, we evaluated the efficacy and safety of ... machines" can replace " ;the brain and hand, skill and experience" of the specialist. The aim of this study was to verify the reliability and efficacy of one of these compact portable diode ... inconvenience delays the patients' return to their routine activities. For the principle of selective photothermolysis to be respected Physics imposes a set of "ideal" theo-retical...
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Báo cáo y học: " A Dietary Supplement Containing Standardized Phaseolus vulgaris Extract Influences Body Composition of Overweight Men and Women"
... Aims: The present research study examines a dietary supplement containing 445 mg of Phaseolus vulgaris extract derived from the white kidney bean, previously shown to inhibit the activity of the ... period for any unexpected circum-stances. Upon completion of the study, the envelope was opened in the presence of a representative of the sponsor and of the Principal Investigator, and the representative ... risen dramatically in recent years, their therapeu-tic effectiveness remains uncertain in many cases. Some providers of weight loss products tend to over-hype the utility of dietary supplements...
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Báo cáo y học: "Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy"
... previously that G/G of the PTPN11 gene encoding SHP-2 increased the risk of gastric atrophy among the seropositive subjects [18]. The present study examined the association of a polymorphism of ... from all the subjects. This study protocol was approved by the Ethics Committee of the Nagoya University Graduate School of Medicine. Tests for Helicobacer pylori (H. pylori) antibody and pepsinogens ... through the level of cytokines which are advantageous to eradication of H. pylori. These results should be interpreted with caution. The question is whether these apparently H. pylori-negative...
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Báo cáo y học: " A Practical Approach to Managing Patients with HCV Infection"
... in the history that help identify the possible timing of the infection or the duration of the liver disease include: prior history of injection drug use, former history of transfusion of blood ... weighed by the severity of disease, the predicted success rate, the anticipated adverse effects and the cost and availability of the drugs. The decision to treat should never be made by the physician ... review of the current practice guidelines, the available therapeutic options, and the development of new therapeutic strategies. 2. Natural History of HCV Infection The natural history of HV...
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